Rabbit anti-Human PDE8A Polyclonal Antibody | anti-PDE8A antibody

PDE8A antibody

Cat. Num. AAA535502

• Gene Names: PDE8A; HsT19550
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: PDE8A antibody was purified by affinity chromatography.
• Synonyms: PDE8A; Polyclonal Antibody; PDE8A antibody; Polyclonal PDE8A; Anti-PDE8A; phosphodiesterase 8a; PDEA 8; pde8a; cAMP-specific phosphodiesterase PDE8A; PDEA -8; anti-PDE8A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human
• Purity/Purification: PDE8A antibody was purified by affinity chromatography.
• Form/Format: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 829

• Applicable Applications for anti-PDE8A antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 10 ug/ml
• Biological Significance: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDE1-11; PDE4, 7 and 8 selectively degrade cAMP. These enzymes are involved in many signal transduction pathways.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
• Immunogen: PDE8A antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-PDE8A antibody

Rabbit polyclonal PDE8A antibody

Product Categories/Family for anti-PDE8A antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 27734721
• NCBI GeneID: 5151
• NCBI Accession #: NP_002596
• NCBI GenBank Nucleotide #: NM_002605.2
• UniProt Accession #: O60658; Q6P9H3; Q969I1; Q96PC9; Q96PD0; Q96PD1; Q96T71; Q9UMB7; Q9UMC3; B3KXE6; H0YMZ7
• Molecular Weight: 86,049 Da
• NCBI Official Full Name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 1
• NCBI Official Synonym Full Names: phosphodiesterase 8A
• NCBI Official Symbol: PDE8A
• NCBI Official Synonym Symbols: HsT19550
• NCBI Protein Information: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
• UniProt Protein Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
• Protein Family: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE8A
• UniProt Entry Name: PDE8A_HUMAN

NCBI Description

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

PDE8A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; signal transducer activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: cyclic nucleotide metabolic process; regulation of transcription, DNA-dependent; cAMP catabolic process; two-component signal transduction system (phosphorelay)