Rabbit PDE4D Polyclonal Antibody | anti-PDE4D antibody
Pan PDE4D Antibody FITC-Conjugated
Gene Names
PDE4B; DPDE4; PDEIVB
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Synonyms
PDE4D; Polyclonal Antibody; Pan PDE4D Antibody FITC-Conjugated; cAMP specific 3'; 5' cyclic phosphodiesterase 4D; DKFZp686M11213; 5''-cyclic phosphodiesterase 4D; cAMP specific phosphodiesterase PDE4D; cAMP specific phosphodiesterase PDE4D6; DPDE 3; Dunce like phosphodiesterase E3; FLJ97311; HSPDE4D; PDE 43; PDE4DN2; Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3); Drosophila; STRK1 antibody; anti-PDE4D antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
This antibody labels all PDE4D proteins including PDE4D1, PDE4D2, PDE4D3, PDE4D4, and PDE4D5 variants. Does not cross react with PDE4A, PDE4B, PDE4D6, PDE4D7, PDE4D8, PDE4D9, OR PDE4C.
Form/Format
FITC-Conjugated
Concentration
0.57 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
736
Applicable Applications for anti-PDE4D antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500
Immunogen
C-terminal cyclic peptide unique to all PDED subtypes variants.
Expression
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Molecular Function
Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Structure
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1).
Subcellular Location
Apical cell membrane, Cytoplasm, Membrane
Preparation and Storage
-20 degree C for long term storage
Related Product Information for anti-PDE4D antibody
FITC-Conjugated Phosphodiesterase 4D Antibody
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
57,709 Da
NCBI Official Full Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
NCBI Official Synonym Full Names
phosphodiesterase 4B
NCBI Official Symbol
PDE4B
NCBI Official Synonym Symbols
DPDE4; PDEIVB
NCBI Protein Information
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt Protein Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Protein Family
UniProt Gene Name
PDE4B
UniProt Synonym Gene Names
DPDE4
UniProt Entry Name
PDE4B_HUMAN
NCBI Description
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Uniprot Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Research Articles on PDE4D
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Product Notes
The PDE4D pde4b (Catalog #AAA543542) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Pan PDE4D Antibody FITC-Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PDE4D can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:150 Western Blot: 1:500. Researchers should empirically determine the suitability of the PDE4D pde4b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE4D, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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