Rabbit anti-Human PDE3A Polyclonal Antibody | anti-PDE3A antibody

PDE3A antibody

Cat. Num. AAA535539

• Gene Names: PDE3A; HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: PDE3A antibody was purified by affinity chromatography.
• Synonyms: PDE3A; Polyclonal Antibody; PDE3A antibody; Polyclonal PDE3A; Anti-PDE3A; cGMP-inhibited phosphodiesterase 3A; cGMP-inhibited 3'; PDEA -3; cGIP2; cAMP Phosphodiesterase; PDEA 3; CGI-PDE A; 5'-cyclic phosphodiesterase A; MYOCARDIAL cGMP-inhibited; Cyclic GMP inhibited phos; anti-PDE3A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human
• Purity/Purification: PDE3A antibody was purified by affinity chromatography.
• Form/Format: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 1141

• Applicable Applications for anti-PDE3A antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 20 ug/ml
• Biological Significance: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDE1, 2, 3, 10 and 11 degrade bothcyclic nucleotides. These enzymes are involved in many signal transduction pathways.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
• Immunogen: PDE3A antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-PDE3A antibody

Rabbit polyclonal PDE3A antibody

Product Categories/Family for anti-PDE3A antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 70608155
• NCBI GeneID: 5139
• NCBI Accession #: NP_000912
• NCBI GenBank Nucleotide #: NM_000921.4
• UniProt Accession #: Q14432; O60865; Q13348; Q17RD1
• Molecular Weight: 124,979 Da
• NCBI Official Full Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform 1
• NCBI Official Synonym Full Names: phosphodiesterase 3A, cGMP-inhibited
• NCBI Official Symbol: PDE3A
• NCBI Official Synonym Symbols: HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
• NCBI Protein Information: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
• UniProt Protein Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
• Protein Family: cGMP-inhibited 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE3A
• UniProt Synonym Gene Names: CGI-PDE A
• UniProt Entry Name: PDE3A_HUMAN

NCBI Description

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.

Protein type: Membrane protein, integral; EC 3.1.4.17; Phosphodiesterase; Membrane protein, multi-pass; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: integral to membrane; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; cAMP binding

Biological Process: response to drug; diterpenoid metabolic process; cAMP-mediated signaling; response to cAMP; cGMP-mediated signaling; cAMP catabolic process; negative regulation of vascular permeability; regulation of meiosis; lipid metabolic process; blood coagulation; oocyte maturation; positive regulation of vascular permeability; negative regulation of apoptosis

Disease: Hypertension And Brachydactyly Syndrome