Western Blot (WB)
(PCDHB3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PCDHB3 antibody detected the PCDHB3 protein (arrow).)
Rabbit anti-Human PCDHB3 Polyclonal Antibody | anti-PCDHB3 antibody
PCDHB3 Antibody (N-term)
Western Blot (WB)
(PCDHB3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PCDHB3 antibody detected the PCDHB3 protein (arrow).)
Western Blot (WB)
(PCDHB3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PCDHB3 antibody detected the PCDHB3 protein (arrow).)
Immunohistochemistry (IHC)
(PCDHB3 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHB3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PCDHB3 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHB3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of PCDHB3 Antibody (N-term) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of PCDHB3 Antibody (N-term) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
cluster, one of three related gene clusters tandemly linked on
chromosome five. The gene clusters demonstrate an unusual genomic
organization similar to that of B-cell and T-cell receptor gene
clusters. The beta cluster contains 16 genes and 3 pseudogenes,
each encoding 6 extracellular cadherin domains and a cytoplasmic
tail that deviates from others in the cadherin superfamily. The
extracellular domains interact in a homophilic manner to specify
differential cell-cell connections. Unlike the alpha and gamma
clusters, the transcripts from these genes are made up of only one
large exon, not sharing common 3' exons as expected. These neural
cadherin-like cell adhesion proteins are integral plasma membrane
proteins. Their specific functions are unknown but they most likely
play a critical role in the establishment and function of specific
cell-cell neural connections.
Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :
Wu, Q., et al. Genome Res. 11(3):389-404(2001)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
Uniprot Description
PCDHB3: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: integral to plasma membrane; integral to membrane
Molecular Function: calcium ion binding
Biological Process: nervous system development; synaptic transmission; synaptogenesis; calcium-dependent cell-cell adhesion; homophilic cell adhesion; cell adhesion
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Product Notes
The PCDHB3 pcdhb3 (Catalog #AAA9214444) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 12-39. The PCDHB3 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PCDHB3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF). WB~~1:1000. Researchers should empirically determine the suitability of the PCDHB3 pcdhb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCDHB3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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