Mouse anti-Human PCDH8 Polyclonal Antibody | anti-PCDH8 antibody

PCDH8 (Protocadherin-8, Arcadlin)

Cat. Num. AAA646085

• Gene Names: PCDH8; PAPC; ARCADLIN
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PCDH8; Polyclonal Antibody; PCDH8 (Protocadherin-8; Arcadlin); Anti -PCDH8 (Protocadherin-8; anti-PCDH8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PCDH8.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGCPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV

• Applicable Applications for anti-PCDH8 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human PCDH8, aa1-1070 (AAH36025.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PCDH8 expression in transfected 293T cell line by PCDH8 polyclonal antibody. Lane 1: PCDH8 transfected lysate (117.7kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-PCDH8 antibody

Antibodies; Abs to Cadherin

NCBI and Uniprot Product Information

• NCBI GI #: 14589937
• NCBI GeneID: 5100
• NCBI Accession #: NP_116567.1
• NCBI GenBank Nucleotide #: NM_032949.2
• UniProt Accession #: O95206; Q5TAN1; Q5TAN2; Q8IYE9; Q96SF1; B4DMV7
• Molecular Weight: 113,019 Da
• NCBI Official Full Name: protocadherin-8 isoform 2
• NCBI Official Synonym Full Names: protocadherin 8
• NCBI Official Symbol: PCDH8
• NCBI Official Synonym Symbols: PAPC; ARCADLIN
• NCBI Protein Information: protocadherin-8
• UniProt Protein Name: Protocadherin-8
• Protein Family: Protocadherin
• UniProt Gene Name: PCDH8
• UniProt Entry Name: PCDH8_HUMAN

NCBI Description

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Calcium-dependent cell-adhesion protein

By similarity. May play a role in activity-induced synaptic reorganization underlying long term memory

By similarity. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis

By similarity.

Subunit structure: The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis

By similarity. Interacts with CDH2; this interaction may lead to CDH2 cointernalization

By similarity. Interacts with CDH11

By similarity. Interacts with TAOK2

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity. Cell projection › dendrite

By similarity. Cell junction › synapse › presynaptic cell membrane. Cell junction › synapse › postsynaptic cell membrane. Note: Also expressed in neuronal cell bodies

By similarity. Localized to excitatory, but not with inhibitory, synapses

By similarity.

Sequence similarities: Contains 6 cadherin domains.