Western Blot (WB)
(Western Blot analysis of various cells with Phospho-Paxillin (Tyr88) Polyclonal Antibody )
Rabbit anti-Human Paxillin Polyclonal Antibody | anti-Pxn antibody
Phospho-Paxillin (Y88) Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of various cells with Phospho-Paxillin (Tyr88) Polyclonal Antibody )
Western Blot (WB)
(Western Blot analysis of various cells with Phospho-Paxillin (Tyr88) Polyclonal Antibody )
NCBI and Uniprot Product Information
Uniprot Description
PXN: a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase.
Protein type: Cytoskeletal; Cell adhesion; Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: cell cortex; cytoplasm; cytoskeleton; focal adhesion; lamellipodium; leading edge; nucleoplasm; plasma membrane; stress fiber
Molecular Function: beta-catenin binding; BH4 domain binding; integrin binding; protein complex binding; protein kinase binding; vinculin binding; zinc ion binding
Biological Process: activation of MAPK activity; branching morphogenesis of a tube; cell-matrix adhesion; cytoskeleton organization and biogenesis; focal adhesion formation; integrin-mediated signaling pathway; lamellipodium biogenesis; peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; regulation of cell shape; transforming growth factor beta receptor signaling pathway
Research Articles on Pxn
Similar Products
Product Notes
The Pxn pxn (Catalog #AAA2538708) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-Paxillin (Y88) Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Paxillin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the Pxn pxn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Paxillin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
