Rabbit anti-Human Parathyroid Hormone, MidRegion Polyclonal Antibody | anti-Pth antibody

Parathyroid Hormone, MidRegion (PTH)

Cat. Num. AAA613205

• Gene Names: Pth; Pthp; MGC117651
• Reactivity: Human
• Purity: Serum; Neat serum.
• Synonyms: Parathyroid Hormone; MidRegion; Polyclonal Antibody; MidRegion (PTH); Anti -Parathyroid Hormone; anti-Pth antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mid region of Human Glandular PTH.
• Purity/Purification: Serum; Neat serum.
• Form/Format: Supplied as a liquid, neat serum.

• Application Notes: Dilution: ELISA, RIA: 1:20,000
• Immunogen: Human Glandular PTH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Pth antibody

Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin. Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body. PTH half-life is approximately 4 minutes. PTH enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH; rather, PTH binds to osteoblasts, the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL, which can bind to osteoclast precursors containing RANK, a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse, forming new osteoclasts which ultimately enhances the resorption of bone.

Product Categories/Family for anti-Pth antibody

Antibodies; Abs to Hormones; Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 10181174
• NCBI GeneID: 19226
• NCBI Accession #: NP_065648.1
• NCBI GenBank Nucleotide #: NM_020623.2
• UniProt Accession #: Q9Z0L6
• Molecular Weight: 12,825 Da
• NCBI Official Full Name: parathyroid hormone
• NCBI Official Synonym Full Names: parathyroid hormone
• NCBI Official Symbol: Pth
• NCBI Official Synonym Symbols: Pthp; MGC117651
• NCBI Protein Information: parathyroid hormone
• UniProt Protein Name: Parathyroid hormone
• Protein Family: Parathyroid hormone
• UniProt Gene Name: Pth
• UniProt Entry Name: Q9Z0L6_MOUSE

Uniprot Description

PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.

Protein type: Hormone; Secreted, signal peptide; Apoptosis; Secreted

Cellular Component: extracellular space; cell; intracellular

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; parathyroid hormone receptor binding; peptide hormone receptor binding; hormone activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of signal transduction; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; positive regulation of ossification; Rho protein signal transduction; cellular calcium ion homeostasis; positive regulation of glucose import; cell-cell signaling; regulation of gene expression; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption

Disease: Hypoparathyroidism, Familial Isolated