Western Blot (WB)
(Western blot analysis of PALMD in human bladder tissue lysate with PALMD antibody at 1 μg/ml.)
Rabbit anti-Human PALMD Polyclonal Antibody | anti-PALMD antibody
PALMD Antibody
Gene Names
PALMD; PALML; C1orf11
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column.
Synonyms
PALMD; Polyclonal Antibody; PALMD Antibody; Palmdelphin; C1orf11; FLJ20271; PALML; Paralemnin-like protein; anti-PALMD antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
PALMD antibody is human specific. At least two isoforms are known to exist.
Purity/Purification
Affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
551
Applicable Applications for anti-PALMD antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.
Immunogen
PALMD antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PALMD.
Buffer
Supplied in PBS containing 0.02% sodium azide.
Positive Control 1
Human Bladder Tissue Lysate
Conjugate
Unconjugated
Preparation and Storage
Store at 4 degree C for three months and -20 degree C, stable for up to one year.
Western Blot (WB)
(Western blot analysis of PALMD in human bladder tissue lysate with PALMD antibody at 1 μg/ml.)
Western Blot (WB)
(Western blot analysis of PALMD in human bladder tissue lysate with PALMD antibody at 1 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of PALMD in human bladder tissue with PALMD antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of PALMD in human bladder tissue with PALMD antibody at 2.5 μg/mL.)
Related Product Information for anti-PALMD antibody
Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2). While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3). PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5). Abnormal genetic alterations in PALMD are observed in many malignant tumors (5).
References
Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850. Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40. Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76. Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 61 kDa
Observed: 60 kDa
Observed: 60 kDa
NCBI Official Full Name
palmdelphin
NCBI Official Synonym Full Names
palmdelphin
NCBI Official Symbol
PALMD
NCBI Official Synonym Symbols
PALML; C1orf11
NCBI Protein Information
palmdelphin
UniProt Protein Name
Palmdelphin
Protein Family
UniProt Gene Name
PALMD
UniProt Synonym Gene Names
C1orf11; PALML
UniProt Entry Name
PALMD_HUMAN
Uniprot Description
PALMD: Belongs to the paralemmin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1p21.2
Cellular Component: cytoplasm; dendritic spine; membrane
Biological Process: regulation of cell shape
Research Articles on PALMD
Similar Products
Product Notes
The PALMD palmd (Catalog #AAA154389) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PALMD Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PALMD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). PALMD antibody can be used for detection of PALMD by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. Researchers should empirically determine the suitability of the PALMD palmd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PALMD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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