PAF65alpha Polyclonal Antibody | anti-PAF65alpha antibody

PAF65alpha Polyclonal Antibody

Cat. Num. AAA8524546

• Gene Names: TAF6L; PAF65A
• Synonyms: PAF65alpha; Polyclonal Antibody; PAF65alpha Polyclonal Antibody; anti-PAF65alpha antibody

• Clonality: Polyclonal
• Sequence Length: 622

NCBI and Uniprot Product Information

• NCBI GI #: 5453844
• NCBI GeneID: 10629
• NCBI Accession #: NP_006464.1
• NCBI GenBank Nucleotide #: NM_006473.3
• UniProt Accession #: Q9Y6J9; Q96HA6; B2RAT0
• Molecular Weight: 67,814 Da
• NCBI Official Full Name: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor 6 like
• NCBI Official Symbol: TAF6L
• NCBI Official Synonym Symbols: PAF65A
• NCBI Protein Information: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
• UniProt Protein Name: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
• UniProt Gene Name: TAF6L
• UniProt Synonym Gene Names: PAF65A; PAF65-alpha

NCBI Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.