Rabbit anti-Human, Mouse PADI6 Polyclonal Antibody | anti-PADI6 antibody

PADI6, NT (PADI6, Protein-arginine deiminase type-6, Peptidylarginine deiminase VI, Protein-arginine deiminase type VI) (MaxLight 490)

Cat. Num. AAA6330445

• Gene Names: PADI6; hPADVI; PREMBL2
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: PADI6; Polyclonal Antibody; NT (PADI6; Protein-arginine deiminase type-6; Peptidylarginine deiminase VI; Protein-arginine deiminase type VI) (MaxLight 490); Protein-arginine deiminase type VI; anti-PADI6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PADI6. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-PADI6 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 196-223 from the N-terminal region of human PADI6. UniProt Accession: Q6TGC4.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse stomach tissue lysates (35ug/lane) usingMBS643484. This demonstrates MBS643484 detected the PADI6 protein (arrow).)

Related Product Information for anti-PADI6 antibody

Peptidylarginine deiminases (PADs, EC 3.5.3.15), including PADI6, make up a family of posttranslational protein modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ions.

Product Categories/Family for anti-PADI6 antibody

Antibodies; Enzymes

References

1. Stacey, S.N., et al. Nat. Genet. 40(11):1313-1318(2008). 2. Chavanas, S., et al. Gene 330:19-27 (2004). 3. Zhang, J., et al. Acta Biochim. Pol. 51(4):1051-1058(2004). 4. Vossenaar, E.R., et al. Bioessays 25(11):1106-1118(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 117414158
• NCBI GeneID: 353238
• NCBI Accession #: NP_997304.3
• NCBI GenBank Nucleotide #: NM_207421.4
• UniProt Accession #: Q6TGC4; Q330K5; Q70SX3
• Molecular Weight: 77,727 Da
• NCBI Official Full Name: protein-arginine deiminase type-6
• NCBI Official Synonym Full Names: peptidyl arginine deiminase 6
• NCBI Official Symbol: PADI6
• NCBI Official Synonym Symbols: hPADVI; PREMBL2
• NCBI Protein Information: protein-arginine deiminase type-6
• UniProt Protein Name: Protein-arginine deiminase type-6
• Protein Family: Protein-arginine deiminase
• UniProt Gene Name: PADI6
• UniProt Synonym Gene Names: PAD6; hPADVI

NCBI Description

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

Uniprot Description

PADI6: Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo. Belongs to the protein arginine deiminase family.

Protein type: Cytoskeletal; EC 3.5.3.15; Hydrolase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytoplasm; intermediate filament cytoskeleton; nucleus

Molecular Function: calcium ion binding; protein-arginine deiminase activity

Biological Process: cytoplasm organization and biogenesis; cytoskeleton organization; regulation of translation by machinery localization

Disease: Preimplantation Embryonic Lethality 2