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Western Blot (WB) (Western blot analysis of extracts of various celllines, using PACSIN1antibody.)

Rabbit PACSIN1 Polyclonal Antibody | anti-PACSIN1 antibody

PACSIN1 Polyclonal Antibody

Gene Names
PACSIN1; SDPI
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Affinity purification
Synonyms
PACSIN1; Polyclonal Antibody; PACSIN1 Polyclonal Antibody; KIAA1379; SDPI; anti-PACSIN1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purification
Sequence Length
444
Applicable Applications for anti-PACSIN1 antibody
Western Blot (WB)
Application Notes
WB: 1:200-1:500
Immunogen
Recombinant protein of human PACSIN1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various celllines, using PACSIN1antibody.)

Western Blot (WB) (Western blot analysis of extracts of various celllines, using PACSIN1antibody.)
Related Product Information for anti-PACSIN1 antibody
PACSINs are members of a family of cytoplasmic adapter proteins, which share a conserved C-terminal protein binding SH3 domain and a CDC15-NT domain. PACSIN 1-related proteins include syndapin 1 (the rat homolog of PACSIN 1), FAP52, EM13, and PSTPIP, all of which seem to be involved in signaling pathways associated with cytoskeletal organization. PACSIN 1 expression is restricted to terminally differentiated neural tissue, whereas PACSIN 2 is widely expressed. PACSIN 2 shows vesicle-like distribution and may be involved in regulating endocytotic processes.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
51kDa
NCBI Official Full Name
protein kinase C and casein kinase substrate in neurons protein 1
NCBI Official Synonym Full Names
protein kinase C and casein kinase substrate in neurons 1
NCBI Official Symbol
PACSIN1
NCBI Official Synonym Symbols
SDPI
NCBI Protein Information
protein kinase C and casein kinase substrate in neurons protein 1
UniProt Protein Name
Protein kinase C and casein kinase substrate in neurons protein 1
UniProt Gene Name
PACSIN1
UniProt Synonym Gene Names
KIAA1379

Uniprot Description

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (). Binds to membranes via its F-BAR domain and mediates membrane tubulation.

Research Articles on PACSIN1

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Product Notes

The PACSIN1 pacsin1 (Catalog #AAA8527401) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PACSIN1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PACSIN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:200-1:500. Researchers should empirically determine the suitability of the PACSIN1 pacsin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PACSIN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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