Rabbit PA2G4 Polyclonal Antibody | anti-PA2G4 antibody

PA2G4 Polyclonal Antibody

Cat. Num. AAA3011158

• Gene Names: PA2G4; EBP1; HG4-1; p38-2G4
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PA2G4; Polyclonal Antibody; PA2G4 Polyclonal Antibody; 38kDa; AA672939; Cell cycle protein p38 2G4 homolog; Cell cycle protein p38-2G4 homolog; ErbB-3 binding protein 1; ErbB3 binding protein 1; ErbB3-binding protein 1; ErbB3-binding protein Ebp1; hG4 1; hG4-1; IRES-specific cellular trans-acting factor 45 kDa; MGC81621; MGC94070; Mpp1; p38 2G4; PA2G4_HUMAN; Plfap; Proliferation associated 2G4; 38-KD; Proliferation-associated 2G4; a; Proliferation-associated protein 1; Proliferation-associated protein 2G4; Protein p38-2G4; si: dz150i12.2; wu: fb19b11; wu: ft56d05; zgc: 86732; anti-PA2G4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PA2G4 polyclonal antibody detects endogenous levels of PA2G4 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 394

• Applicable Applications for anti-PA2G4 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human PA2G4.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of PA2G4 polyclonal antibody)

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analysis of PA2G4 polyclonal antibody in paraffin-embedded Human Stomach Cancer tissue.)

Immunofluorescence (IF)

(Immunofluorescence analysis of U2OS cells, using PA2G4 polyclonal antibody)

Related Product Information for anti-PA2G4 antibody

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals.

NCBI and Uniprot Product Information

• NCBI GI #: 124494254
• NCBI GeneID: 5036
• NCBI Accession #: NP_006182.2
• NCBI GenBank Nucleotide #: NP_006182.2
• UniProt Accession #: Q9UQ80
• Molecular Weight: ~43kDa
• NCBI Official Full Name: proliferation-associated protein 2G4
• NCBI Official Synonym Full Names: proliferation-associated 2G4
• NCBI Official Symbol: PA2G4
• NCBI Official Synonym Symbols: EBP1; HG4-1; p38-2G4
• NCBI Protein Information: proliferation-associated protein 2G4
• UniProt Protein Name: Proliferation-associated protein 2G4
• Protein Family: Proliferation-associated protein
• UniProt Gene Name: PA2G4
• UniProt Synonym Gene Names: EBP1; hG4-1
• UniProt Entry Name: PA2G4_HUMAN

NCBI Description

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

Ebp1: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Belongs to the peptidase M24 family.

Protein type: Nucleolus; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; DNA binding; ubiquitin protein ligase binding; transcription factor activity

Biological Process: regulation of translation; cell proliferation; transcription, DNA-dependent; positive regulation of cell differentiation; negative regulation of transcription, DNA-dependent; cell cycle arrest; rRNA processing; negative regulation of apoptosis