Rabbit p63 Polyclonal Antibody | anti-p63 antibody

p63 Rabbit Polyclonal

Cat. Num. AAA7602321

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: p63; Polyclonal Antibody; p63 Rabbit Polyclonal; anti-p63 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 566

• Applicable Applications for anti-p63 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Tumor protein p63
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using MBS7602321 (TP63 Antibody) at dilution of 1:100)

Western Blot (WB)

(A431 cells were subjected to SDS PAGE followed by western blot with MBS7602321 (TP63 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 243486
• NCBI GeneID: 994
• Molecular Weight: 67,241 Da
• NCBI Official Full Name: p63
• NCBI Official Synonym Full Names: cell division cycle 25B
• NCBI Official Symbol: CDC25B
• NCBI Protein Information: M-phase inducer phosphatase 2
• UniProt Protein Name: M-phase inducer phosphatase 2
• UniProt Gene Name: CDC25B
• UniProt Synonym Gene Names: CDC25HU2
• UniProt Entry Name: MPIP2_HUMAN

NCBI Description

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

Uniprot Description

CDC25B: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described.

Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; spindle pole

Molecular Function: phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity

Biological Process: cell division; female meiosis I; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle; oocyte maturation; positive regulation of cell proliferation; positive regulation of cytokinesis; positive regulation of mitotic cell cycle; positive regulation of protein kinase activity; protein amino acid phosphorylation