Guinea pig p62 Polyclonal Antibody | anti-KHDRBS1 antibody

p62, CT

Cat. Num. AAA641828

• Gene Names: KHDRBS1; p62; p68; Sam68
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry
• Purity: Serum; Serum
• Synonyms: p62; Polyclonal Antibody; CT; Anti -p62; anti-KHDRBS1 antibody

• Host: Guinea pig
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human p62 protein. Stains neurofibrillary tangles in the brain of patients suffering from Alzheimer's disease. Species Crossreactivity
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid with 0.09% sodium azide.

• Applicable Applications for anti-KHDRBS1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.; Dilution: Immunohistochemistry (Frozen and paraffin sections, enhanced after microwave treatment): 1:100-1:200; Incubation Time 1 hr at RT; extended with paraffin sections.; Western Blot: 1:1000-1:2000 (ECL)
• Immunogen: C-terminal domain, C-NYDIGAALDTIQYSKHPPPL of human p62 protein, conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-KHDRBS1 antibody

Human 62 kD (p62) protein is present in intracytoplasmic inclusions (e.g. hyaline bodies) of hepatocellular carcinoma. p62 protein has been found in many tissues and cells, including lymphoid cells, probably serving a common cellular signal transduction mechanism.

Product Categories/Family for anti-KHDRBS1 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 189500
• NCBI GeneID: 10657
• UniProt Accession #: Q07666; Q6PJX7; Q8NB97; Q99760; D3DPP3
• Molecular Weight: 48,227 Da
• NCBI Official Full Name: p62
• NCBI Official Synonym Full Names: KH domain containing, RNA binding, signal transduction associated 1
• NCBI Official Symbol: KHDRBS1
• NCBI Official Synonym Symbols: p62; p68; Sam68
• NCBI Protein Information: KH domain-containing, RNA-binding, signal transduction-associated protein 1; src-associated in mitosis 68 kDa protein; p21 Ras GTPase-activating protein-associated p62; GAP-associated tyrosine phosphoprotein p62 (Sam68)
• UniProt Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 1
• Protein Family: KH domain-containing, RNA-binding, signal transduction-associated protein
• UniProt Gene Name: KHDRBS1
• UniProt Synonym Gene Names: SAM68; Sam68
• UniProt Entry Name: KHDR1_HUMAN

NCBI Description

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Description

KHDRBS1: a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear ribonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; SH3/SH2 adaptor activity; RNA binding; protein complex binding; poly(U) binding; SH3 domain binding; poly(A) binding

Biological Process: transcription, DNA-dependent; positive regulation of signal transduction; positive regulation of RNA export from nucleus; regulation of protein stability; signal transduction; positive regulation of translational initiation; cell proliferation; cell surface receptor linked signal transduction; regulation of RNA export from nucleus; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; mRNA processing; cell cycle arrest