Testing Data
(P2YR8 staining of paraffin embedded human brain tissue.)
Rabbit anti-Human P2YR8 Polyclonal Antibody | anti-P2YR8 antibody
P2YR8
Gene Names
P2RY8; P2Y8
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
P2YR8; Polyclonal Antibody; anti-P2YR8 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Form/Format
Affinity Purified antibody
Liquid. Phosphate buffered saline containing 0.1% sodium azide
Liquid. Phosphate buffered saline containing 0.1% sodium azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-P2YR8 antibody
Immunohistochemistry (IHC)
Immunogen
C-terminal cytoplasmic domain of human. Synthetic peptide-KLH conjugated.
Preparation and Storage
Long term: -70 degree C; Short term: 4 degree C. Repeated freeze/thaw cycles compromise the integrity of the antibody.
Testing Data
(P2YR8 staining of paraffin embedded human brain tissue.)
Testing Data
(P2YR8 staining of paraffin embedded human brain tissue.)
Related Product Information for anti-P2YR8 antibody
P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells.
*Note on Orphan Receptors: Since supporting data from binding studies and ligand-mapping studies are not available, and evaluation of the specificity and validity of our IHC findings relies more heavily on cross-concordant findings with multiple antibodies and on gene expression studies such as Northern-blot analysis or in situ hybridization. Generally, proteins that are detectable within a particular type of tissue by Northern-blot analysis are also detectable by IHC. Although it is possible for a gene to be transcribed within a tissue but not translated, our experience has been that a positive finding on a human tissue Northern blot generally correlates with the ability to detect the protein within that tissue by IHC.
Northern analysis can, however, underestimate the presence of low-copy mRNAs or those that are expressed by only a small subset of cells within a tissue. In situ hybridization (ISH) is a more sensitive method for the detection of low-abundance genes, because mRNA can be localized to individual cells within a tissue sample. However, this method does not lend itself readily to high-throughput, first-pass screening in formalin-fixed, paraffin-embedded tissue specimens, and many cell types may produce mRNAs that are below the limit of sensitivity of detection by colorimetric or radiometric ISH.
*Note on Orphan Receptors: Since supporting data from binding studies and ligand-mapping studies are not available, and evaluation of the specificity and validity of our IHC findings relies more heavily on cross-concordant findings with multiple antibodies and on gene expression studies such as Northern-blot analysis or in situ hybridization. Generally, proteins that are detectable within a particular type of tissue by Northern-blot analysis are also detectable by IHC. Although it is possible for a gene to be transcribed within a tissue but not translated, our experience has been that a positive finding on a human tissue Northern blot generally correlates with the ability to detect the protein within that tissue by IHC.
Northern analysis can, however, underestimate the presence of low-copy mRNAs or those that are expressed by only a small subset of cells within a tissue. In situ hybridization (ISH) is a more sensitive method for the detection of low-abundance genes, because mRNA can be localized to individual cells within a tissue sample. However, this method does not lend itself readily to high-throughput, first-pass screening in formalin-fixed, paraffin-embedded tissue specimens, and many cell types may produce mRNAs that are below the limit of sensitivity of detection by colorimetric or radiometric ISH.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
40,635 Da
NCBI Official Full Name
P2Y purinoceptor 8
NCBI Official Synonym Full Names
purinergic receptor P2Y, G-protein coupled, 8
NCBI Official Symbol
P2RY8
NCBI Official Synonym Symbols
P2Y8
NCBI Protein Information
P2Y purinoceptor 8; G-protein coupled purinergic receptor P2Y8
UniProt Protein Name
P2Y purinoceptor 8
UniProt Gene Name
P2RY8
UniProt Synonym Gene Names
P2Y8
UniProt Entry Name
P2RY8_HUMAN
NCBI Description
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Uniprot Description
P2RY8: Probable receptor for purines coupled to G-proteins. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.33; Yp11.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: purinergic nucleotide receptor activity, G-protein coupled
Research Articles on P2YR8
Similar Products
Product Notes
The P2YR8 p2ry8 (Catalog #AAA556416) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The P2YR8 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's P2YR8 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the P2YR8 p2ry8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2YR8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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