Western Blot (WB)
(Western blot analysis of P2X1 expression in K562 (A), A549 (B), SP2/0 (C), PC12 (D) whole cell lysates.)
Rabbit P2X1 Polyclonal Antibody | anti-P2RX1 antibody
Anti-P2X1 Antibody
Western Blot (WB)
(Western blot analysis of P2X1 expression in K562 (A), A549 (B), SP2/0 (C), PC12 (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of P2X1 expression in K562 (A), A549 (B), SP2/0 (C), PC12 (D) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Uniprot Description
P2X1: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: postsynaptic membrane; neuron projection; protein complex; integral to plasma membrane; plasma membrane; integral to nuclear inner membrane; lipid raft
Molecular Function: zinc ion binding; calcium channel activity; cation channel activity; drug binding; purinergic nucleotide receptor activity; ATP binding; ATP-gated cation channel activity
Biological Process: caspase activation; platelet activation; synaptic transmission, glutamatergic; vasoconstriction; protein heterooligomerization; insemination; generation of action potential; regulation of calcium ion transport; signal transduction; response to ATP; serotonin secretion by platelet; transport; regulation of blood pressure; regulation of vascular smooth muscle contraction; ceramide biosynthetic process; ion transport; positive regulation of ion transport; blood coagulation; cation transport; protein homooligomerization
Disease: Bleeding Disorder, Platelet-type, 8
Research Articles on P2RX1
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Product Notes
The P2RX1 p2rx1 (Catalog #AAA821241) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-P2X1 Antibody reacts with Human, Mouse, Rat, Monkey, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's P2X1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the P2RX1 p2rx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2X1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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