Rabbit anti-Human P2RY11 Polyclonal Antibody | anti-P2RY11 antibody

P2RY11 Rabbit pAb

Cat. Num. AAA4754730

• Gene Names: P2RY11; P2Y11
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: P2RY11; Polyclonal Antibody; P2RY11 Rabbit pAb; anti-P2RY11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-P2RY11 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Synthetic peptide of human P2RY11
• Conjugation: Unconjugated
• Molecular Function: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
• Modification: Unmodified
• Cell Position: Cell membrane, Membrane
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Human fetal brain tissue, 293T and Hela cell lysates, Primary antibody: 160985(P2RY11 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 160985(P2RY11 Antibody) at dilution 1/30. (Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human brain tissue using 160985(P2RY11 Antibody) at dilution 1/30. (Original magnification: ×200))

Product Categories/Family for anti-P2RY11 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 23463303
• NCBI GeneID: 5032
• NCBI Accession #: NP_002557
• NCBI GenBank Nucleotide #: NM_002566
• UniProt Accession #: Q96G91; O43190; Q9BYU4; Q9H170; B2R8X9
• Molecular Weight: 40,345 Da
• NCBI Official Full Name: P2Y purinoceptor 11
• NCBI Official Synonym Full Names: purinergic receptor P2Y, G-protein coupled, 11
• NCBI Official Symbol: P2RY11
• NCBI Official Synonym Symbols: P2Y11
• NCBI Protein Information: P2Y purinoceptor 11; purinergic receptor P2Y11
• UniProt Protein Name: P2Y purinoceptor 11
• Protein Family: P2Y purinoceptor
• UniProt Gene Name: P2RY11
• UniProt Synonym Gene Names: P2Y11
• UniProt Entry Name: P2Y11_HUMAN

Uniprot Description

P2RY11: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ATP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled; receptor activity; neurotransmitter receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; adenylate cyclase activation; calcium-mediated signaling; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); defense response; adenosine receptor signaling pathway