Rabbit anti-Human, Mouse OXTR Polyclonal Antibody | anti-OXTR antibody

OXTR, NT (OXTR, Oxytocin receptor) (PE)

Cat. Num. AAA6330064

• Gene Names: OXTR; OT-R
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: OXTR; Polyclonal Antibody; NT (OXTR; Oxytocin receptor) (PE); Oxytocin receptor; anti-OXTR antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human OXTR. Species crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-OXTR antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 8-36 in the N-terminal region of human OXTR, UniProt Accession #P30559.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of MBS6011619 in mouse heart tissue lysates (35ug/lane).This demonstrates the OXTR antibody detected the OXTR protein (arrow).)

Related Product Information for anti-OXTR antibody

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.

Product Categories/Family for anti-OXTR antibody

Antibodies; Receptors

References

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010): Kim, H.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15717-15721(2010). Thompson, R.J., et al. Psychoneuroendocrinology (2010). In press: Tost, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13936-13941(2010). Amrani, Y., et al. Respir. Res. 11, 104 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 32307152
• NCBI GeneID: 5021
• NCBI Accession #: NP_000907.2
• NCBI GenBank Nucleotide #: NM_000916.3
• UniProt Accession #: P30559; Q15071
• Molecular Weight: 42,772 Da
• NCBI Official Full Name: oxytocin receptor
• NCBI Official Synonym Full Names: oxytocin receptor
• NCBI Official Symbol: OXTR
• NCBI Official Synonym Symbols: OT-R
• NCBI Protein Information: oxytocin receptor
• UniProt Protein Name: Oxytocin receptor
• Protein Family: Oxytocin receptor
• UniProt Gene Name: OXTR
• UniProt Synonym Gene Names: OT-R
• UniProt Entry Name: OXYR_HUMAN

NCBI Description

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Uniprot Description

OXTR: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: microvillus; cell-cell adherens junction; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: oxytocin receptor activity; peptide hormone binding; peptide binding; vasopressin receptor activity

Biological Process: lactation; response to peptide hormone stimulus; response to anoxia; heart development; female pregnancy; positive regulation of synaptic transmission, glutamatergic; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; muscle contraction; response to drug; maternal behavior; eating behavior; response to amphetamine; positive regulation of synaptic transmission, GABAergic; social behavior; response to cocaine; sleep; memory; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; positive regulation of synaptogenesis; telencephalon development; regulation of systemic arterial blood pressure by vasopressin; suckling behavior; gut development; response to cytokine stimulus; maternal process involved in parturition; positive regulation of vasoconstriction; sperm ejaculation; response to progesterone stimulus; positive regulation of blood pressure