Rabbit anti-Human OVOL1 Polyclonal Antibody | anti-OVOL1 antibody

OVOL1, NT (OVOL1, Putative transcription factor Ovo-like 1) (Biotin)

Cat. Num. AAA6329979

• Gene Names: OVOL1; HOVO1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: OVOL1; Polyclonal Antibody; NT (OVOL1; Putative transcription factor Ovo-like 1) (Biotin); Putative transcription factor Ovo-like 1; anti-OVOL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-OVOL1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: OVOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human OVOL1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(OVOL1 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the OVOL1 antibody detected the OVOL1 protein (arrow).)

Related Product Information for anti-OVOL1 antibody

This gene encodes a protein highly similar to Drosophila and mouse proteins. In Drosophila the ovo protein plays a critical role in Drosophila oogenesis and cuticle formation. In mice the ovo like protein is involved in hair formation and spermatogenesis. The function of the human gene product has not been determined.

Product Categories/Family for anti-OVOL1 antibody

Antibodies; Transcription Factors

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010). Dai, X., et al. Genes Dev. 12(21):3452-3463(1998). Chidambaram, A., et al. Mamm. Genome 8(12):950-951(1997).

NCBI and Uniprot Product Information

• NCBI GI #: 38570158
• NCBI GeneID: 5017
• NCBI Accession #: NP_004552.2
• NCBI GenBank Nucleotide #: NM_004561.3
• UniProt Accession #: O14753; Q6PCB1
• Molecular Weight: 30,259 Da
• NCBI Official Full Name: putative transcription factor Ovo-like 1
• NCBI Official Synonym Full Names: ovo-like 1(Drosophila)
• NCBI Official Symbol: OVOL1
• NCBI Official Synonym Symbols: HOVO1
• NCBI Protein Information: putative transcription factor Ovo-like 1; ovo homolog-like 1
• UniProt Protein Name: Putative transcription factor Ovo-like 1
• Protein Family: Putative transcription factor
• UniProt Gene Name: OVOL1
• UniProt Synonym Gene Names: hOvo1
• UniProt Entry Name: OVOL1_HUMAN

NCBI Description

This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

Uniprot Description

OVOL1: Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system.

Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleus

Molecular Function: metal ion binding

Biological Process: transcription from RNA polymerase II promoter; skin development; epidermal cell differentiation; mesoderm development; spermatogenesis; cytoskeleton organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; germline cell cycle switching, mitotic to meiotic cell cycle