Rabbit anti-Human OTUD6A Polyclonal Antibody | anti-OTUD6A antibody

OTUD6A, ID (OTUD6A, DUBA2, OTU domain-containing protein 6A, DUBA-2) (AP)

Cat. Num. AAA6329922

• Gene Names: OTUD6A; DUBA2; HSHIN6
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: OTUD6A; Polyclonal Antibody; ID (OTUD6A; DUBA2; OTU domain-containing protein 6A; DUBA-2) (AP); DUBA-2; anti-OTUD6A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-OTUD6A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: OTUD6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the Central region of human OTUD6A.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(OTUD6A Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the OTUD6A antibody detected the OTUD6A protein (arrow).)

Related Product Information for anti-OTUD6A antibody

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM].

Product Categories/Family for anti-OTUD6A antibody

Antibodies; Proteins

References

Ota, T., et al. Nat. Genet. 36(1):40-45(2004). Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 46409282
• NCBI GeneID: 139562
• NCBI Accession #: NP_997203.1
• NCBI GenBank Nucleotide #: NM_207320.2
• UniProt Accession #: Q7L8S5; B2RPB7
• Molecular Weight: 33,300 Da
• NCBI Official Full Name: OTU domain-containing protein 6A
• NCBI Official Synonym Full Names: OTU deubiquitinase 6A
• NCBI Official Symbol: OTUD6A
• NCBI Official Synonym Symbols: DUBA2; HSHIN6
• NCBI Protein Information: OTU domain-containing protein 6A
• UniProt Protein Name: OTU domain-containing protein 6A
• Protein Family: OTU domain-containing protein
• UniProt Gene Name: OTUD6A
• UniProt Synonym Gene Names: DUBA2
• UniProt Entry Name: OTU6A_HUMAN

NCBI Description

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

Uniprot Description

OTUD6A: Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains

Protein type: EC 3.4.19.12; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: Xq13.1

Molecular Function: ubiquitin-specific protease activity

Biological Process: proteolysis