Rabbit OTOA Polyclonal Antibody | anti-OTOA antibody

OTOA Polyclonal Antibody

Cat. Num. AAA3015202

• Gene Names: OTOA; CT108; DFNB22
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: OTOA; Polyclonal Antibody; OTOA Polyclonal Antibody; Cancer/testis antigen 108; CT108; Deafness; autosomal recessive 22; DFNB22; OTOAN_HUMAN; Otoancorin; anti-OTOA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: OTOA Polyclonal Antibody detects endogenous levels of OTOA protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-OTOA antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human OTOA/DFNB22
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

Related Product Information for anti-OTOA antibody

Otoancorin, also known as OTOA, CT108 or DFNB22, is a 1,153 amino acid protein belonging to the stereocilin family. Expressed in the inner ear and restricted to the interface between the apical surface of sensory epithelia, otoancorin is suggested to act as an adhesion molecule. Otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in the gene encoding otoancorin leads to deafness autosomal recessive type 22 (DFNB22), which is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain or the area of the brain that receives sound information. Existing as three alternatively spliced isoforms, otoancorin is encoded by a gene located on human chromosome 16p12.2.

NCBI and Uniprot Product Information

• NCBI GI #: 77404409
• NCBI GeneID: 146183
• NCBI Accession #: NP_653273.3
• NCBI GenBank Nucleotide #: NM_144672.3
• UniProt Accession #: Q7RTW8; Q8NA86; Q96M76; A1L3A8; A2VDI0; B3KWU3; E9PF51
• Molecular Weight: 128,533 Da
• NCBI Official Full Name: otoancorin isoform 1
• NCBI Official Synonym Full Names: otoancorin
• NCBI Official Symbol: OTOA
• NCBI Official Synonym Symbols: CT108; DFNB22
• NCBI Protein Information: otoancorin; cancer/testis antigen 108
• UniProt Protein Name: Otoancorin
• Protein Family: Otoancorin
• UniProt Gene Name: OTOA
• UniProt Entry Name: OTOAN_HUMAN

NCBI Description

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

OTOA: May act as an adhesion molecule. Defects in OTOA are the cause of deafness autosomal recessive type 22 (DFNB22). DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the stereocilin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Cancer Testis Antigen (CTA); Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 16p12.2|16p12.2

Cellular Component: proteinaceous extracellular matrix; apical plasma membrane

Biological Process: sensory perception of sound; cell-matrix adhesion; transmission of nerve impulse

Disease: Deafness, Autosomal Recessive 22