Rabbit anti-Human OS9 Polyclonal Antibody | anti-OS9 antibody

OS9 (OS-9, Amplified in Osteosarcoma)

Cat. Num. AAA612466

• Gene Names: OS9; OS-9; ERLEC2
• Reactivity: Human
• Applications: ELISA
• Purity: Purified; Purified
• Synonyms: OS9; Polyclonal Antibody; OS9 (OS-9; Amplified in Osteosarcoma); Anti -OS9 (OS-9; anti-OS9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The specificity of this antibody is unknown. Species Crossreactivity: Species reactivity of this antibody has not been determined. There is 100% identity/homology of the immunogen with the human OS9 protein. There is 94% homology of the immunogen with the mouse and rat OS9 proteins.
• Purity/Purification: Purified; Purified

• Applicable Applications for anti-OS9 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: A C-terminal synthetic peptide made to isoform 1 of the human OS9 protein sequence (between residues 600-667). There are 3 isoforms of this protein. The immunogen used for both of these antibodies is conserved in isoforms 1, 2, and 3 of the human OS9 protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%) Freeze at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-OS9 antibody

OS9 is a novel olfactory protein, also involved in hypoxia.

The theoretical molecular weight of OS9 is ~75.6kD.

Product Categories/Family for anti-OS9 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 17986213
• NCBI GeneID: 10956
• UniProt Accession #: Q13438; O00579; A6NDD1; Q6IBL2; Q9BR60; Q9BW99
• Molecular Weight: 75,562 Da
• NCBI Official Full Name: OS9
• NCBI Official Synonym Full Names: osteosarcoma amplified 9, endoplasmic reticulum lectin
• NCBI Official Symbol: OS9
• NCBI Official Synonym Symbols: OS-9; ERLEC2
• NCBI Protein Information: protein OS-9; erlectin 2; amplified in osteosarcoma 9; endoplasmic reticulum lectin 2; osteosarcoma amplified 9, endoplasmic reticulum associated protein
• UniProt Protein Name: Protein OS-9
• Protein Family: Protein
• UniProt Gene Name: OS9
• UniProt Entry Name: OS9_HUMAN

NCBI Description

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Uniprot Description

OS9: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: endoplasmic reticulum lumen

Molecular Function: protein binding; protease binding; glycoprotein binding; carbohydrate binding

Biological Process: ER-associated protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; protein retention in ER; protein targeting