Rabbit OPRM1 Polyclonal Antibody | anti-OPRM1 antibody

OPRM1 Rabbit pAb

Cat. Num. AAA4759872

• Gene Names: OPRM1; MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: OPRM1; Polyclonal Antibody; OPRM1 Rabbit pAb; opioid receptor mu 1; MOP; MOR; LMOR; MOR1; OPRM; M-OR-1; anti-OPRM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 1.14mg/ml (varies by lot)

• Applicable Applications for anti-OPRM1 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000; IHC-P: 1:50-1:200
• Immunogen: Synthetic peptide of human OPRM1
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of OPRM1 in Human cerebella tissue, A549 cell, RAW264.7 cell lysates in order using OPRM1 Rabbit pAb at dilution 1/800)

Immunohistochemistry (IHC)

(Immunohistochemistry of OPRM1 in paraffin-embedded Human breast cancer tissue using OPRM1 Rabbit pAb at dilution 1/50. Predicted cell location: Cytoplasm)

Related Product Information for anti-OPRM1 antibody

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.

NCBI and Uniprot Product Information

• NCBI GI #: 117940060
• NCBI GeneID: 4988
• NCBI Accession #: NP_000905.3
• NCBI GenBank Nucleotide #: NM_000914.3
• UniProt Accession #: P35372; Q12930; Q4VWM1; Q4VWM2; Q4VWM3; B0FXJ1; B2R9S7; B8Q1L7; B8Q1L8; B8Q1L9; G8XRH6; G8XRH8
• Molecular Weight: 44,779 Da
• NCBI Official Full Name: mu-type opioid receptor isoform MOR-1
• NCBI Official Synonym Full Names: opioid receptor, mu 1
• NCBI Official Symbol: OPRM1
• NCBI Official Synonym Symbols: MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
• NCBI Protein Information: mu-type opioid receptor; mu opiate receptor; mu opioid receptor hMOR-1a
• UniProt Protein Name: Mu-type opioid receptor
• Protein Family: Mu-type opioid receptor
• UniProt Gene Name: OPRM1
• UniProt Synonym Gene Names: MOR1; M-OR-1; MOR-1; MOP; hMOP
• UniProt Entry Name: OPRM_HUMAN

NCBI Description

This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Description

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q24-q25

Cellular Component: dendrite cytoplasm; Golgi apparatus; neuron projection; focal adhesion; endoplasmic reticulum; integral to plasma membrane; plasma membrane; perikaryon; sarcolemma; lipid raft

Molecular Function: voltage-gated calcium channel activity; G-protein coupled receptor activity; protein domain specific binding; neuropeptide binding; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; beta-endorphin receptor activity; filamin binding

Biological Process: positive regulation of nitric oxide biosynthetic process; wound healing; cellular response to stress; locomotory behavior; response to lipopolysaccharide; behavioral response to ethanol; sensory perception of pain; synaptic transmission; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; sensory perception; positive regulation of appetite; dopamine receptor, adenylate cyclase activating pathway; acute inflammatory response to antigenic stimulus; response to food; positive regulation of neurogenesis; negative regulation of nitric oxide biosynthetic process; negative regulation of adenylate cyclase activity; response to cocaine; G-protein signaling, coupled to cyclic nucleotide second messenger; reduction of cytosolic calcium ion concentration; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential

Disease: Epilepsy, Idiopathic Generalized