Immunohistochemistry (IHC)
(Anti-Kappa Opioid Receptor antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit OPRK1 / Kappa Opioid Receptor Polyclonal Antibody | anti-OPRK1 antibody
Rabbit Polyclonal to Human OPRK1 / Kappa Opioid Receptor
Gene Names
OPRK1; KOR; OPRK; KOR-1; K-OR-1
Reactivity
Gibbon, Dog, Horse, Human, Monkey, Rabbit, RatPredicted Reactivity: Gorilla, Mouse, Guinea pig (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
OPRK1 / Kappa Opioid Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human OPRK1 / Kappa Opioid Receptor; Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain) IHC-plus; OPRK1; Kappa-type opioid receptor; Opiate receptor; kappa-1; K-OR-1; KOR; Opioid receptor; kappa 1; OPRK; Ork1; Kappa opioid receptor; KOR-1; Opioid receptor kappa; Human OPRK1; Kappa Opioid Receptor; anti-OPRK1 antibody
Host
Rabbit
Reactivity
Gibbon, Dog, Horse, Human, Monkey, Rabbit, Rat
Predicted Reactivity: Gorilla, Mouse, Guinea pig (at least 90% immunogen sequence identity)
Predicted Reactivity: Gorilla, Mouse, Guinea pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human Kappa Opioid Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
380
Applicable Applications for anti-OPRK1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (4 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from 2nd extracellular domain of human Kappa Opioid Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Horse, Rabbit (100%).
Immunogen Type
Synthetic peptide
Immunogen
OPRK1 / Kappa Opioid Receptor antibody was raised against synthetic 19 amino acid peptide from 2nd extracellular domain of human Kappa Opioid Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Horse, Rabbit (100%); Gorilla, Mouse, Rat, Elephant, Guinea pig (95%); Bat, Bovine, Panda (89%); Opossum (84%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Immunohistochemistry (IHC)
(Anti-Kappa Opioid Receptor antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-Kappa Opioid Receptor antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-OPRK1 antibody
KOR1, an Opioid Receptor, plays a modulatory role in specific aspects of opioid function such as the control of pain. Its endogenous ligand, dynorphin A, is an important neurotransmitter in the central and peripheral nervous systems. KOR1 is believed to mediate sedation, analgesia, and diuresis.
Product Categories/Family for anti-OPRK1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33,319 Da
NCBI Official Full Name
kappa-type opioid receptor isoform 1
NCBI Official Synonym Full Names
opioid receptor, kappa 1
NCBI Official Symbol
OPRK1
NCBI Official Synonym Symbols
KOR; OPRK; KOR-1; K-OR-1
NCBI Protein Information
kappa-type opioid receptor; kappa opioid receptor; Opiate receptor, kappa-1
UniProt Protein Name
Kappa-type opioid receptor
Protein Family
UniProt Gene Name
OPRK1
UniProt Synonym Gene Names
OPRK; K-OR-1; KOR-1
UniProt Entry Name
OPRK_HUMAN
Uniprot Description
KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 8q11.2
Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: neuropeptide binding; protein binding; opioid receptor activity
Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; behavior; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; immune response; regulation of saliva secretion; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain; defense response to virus
Research Articles on OPRK1
Similar Products
Product Notes
The OPRK1 oprk1 (Catalog #AAA247940) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human OPRK1 / Kappa Opioid Receptor reacts with Gibbon, Dog, Horse, Human, Monkey, Rabbit, Rat Predicted Reactivity: Gorilla, Mouse, Guinea pig (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's OPRK1 / Kappa Opioid Receptor can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (4 ug/ml). Researchers should empirically determine the suitability of the OPRK1 oprk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OPRK1 / Kappa Opioid Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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