Rabbit op18 Polyclonal Antibody | anti-op18 antibody

op18 Antibody

Cat. Num. AAA9405575

• Gene Names: STMN1; Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: op18; Polyclonal Antibody; op18 Antibody; oncoprotein 18; STMN1; Stathmin 1; Lag; LAP18; anti-op18 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 149

• Applicable Applications for anti-op18 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide from near the amino terminus of human op18.
• Target Name: op18
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of op18 in human brain tissue lysate with op18 antibody at (A) 0.5 and (B) 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of op18 in human brain tissue with op18 antibody at 2.5 ug/mL.)

Related Product Information for anti-op18 antibody

Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.

Product Categories/Family for anti-op18 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 51895905
• NCBI GeneID: 3925
• Molecular Weight: 19,824 Da
• NCBI Official Full Name: Stathmin 1/oncoprotein 18
• NCBI Official Synonym Full Names: stathmin 1
• NCBI Official Symbol: STMN1
• NCBI Official Synonym Symbols: Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• NCBI Protein Information: stathmin
• UniProt Protein Name: Stathmin
• UniProt Gene Name: STMN1
• UniProt Synonym Gene Names: C1orf215; LAP18; OP18; Op18; pp19
• UniProt Entry Name: STMN1_HUMAN

NCBI Description

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol

Molecular Function: tubulin binding; signal transducer activity

Biological Process: mitotic spindle organization and biogenesis; axonogenesis; negative regulation of microtubule polymerization; response to virus; microtubule depolymerization; positive regulation of cell motility; brain development; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis