Rabbit anti-Human Oct 3/4 Polyclonal Antibody | anti-Oct 3/4 antibody
Oct 3/4 antibody
WB: 1:500-1:1,000
NCBI and Uniprot Product Information
Uniprot Description
Oct4: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2. Transcriptional activity is positively regulated by PKM2. Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Belongs to the POU transcription factor family. Class- 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; transcriptional repressor complex; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein binding; miRNA binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; chromatin binding; transcription corepressor activity; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; negative regulation of calcium ion-dependent exocytosis; endodermal cell fate commitment; somatic stem cell maintenance; multicellular organismal development; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; ectodermal cell fate commitment; negative regulation of transcription from RNA polymerase II promoter; mesodermal cell fate commitment; response to organic substance; regulation of transcription, DNA-dependent; blastocyst growth; cell fate commitment; response to retinoic acid; negative regulation of protein kinase B signaling cascade; transcription, DNA-dependent; stem cell maintenance; germ-line stem cell maintenance; stem cell differentiation; mRNA transcription from RNA polymerase II promoter; trophectodermal cell differentiation; positive regulation of protein kinase B signaling cascade; negative regulation of cell differentiation; regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on Oct 3/4
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Product Notes
The Oct 3/4 pou5f1 (Catalog #AAA535995) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Oct 3/4 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Oct 3/4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:100-1:250 WB: 1:500-1:1,000. Researchers should empirically determine the suitability of the Oct 3/4 pou5f1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Oct 3/4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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