anti-Rabbit, Rat OCT-2 Polyclonal Antibody | anti-OCT-2 antibody
Anti - Oct-2 (Organic Cation Transporter 2)
Gene Names
Orct2; cald; CG13610; DmelCG13610; EP(3)1072; EP1072; orct2
Reactivity
Rabbit, Rat
Applications
ELISA, Western Blot
Purity
Serum
Synonyms
OCT-2; Polyclonal Antibody; Anti - Oct-2 (Organic Cation Transporter 2); Oct-2 (Organic Cation Transporter 2); anti-OCT-2 antibody
Host
Host: Rabbit
Source: Rat
Source: Rat
Reactivity
Rabbit, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat Organic Cation Transporter 2. No significant sequence homology is detected with other Octs or OctNs. Species Sequence Homology
Purity/Purification
Serum
Form/Format
Serum
Supplied as a liquid, neat serum, 0.1% sodium azide, 40% glycerol.
Supplied as a liquid, neat serum, 0.1% sodium azide, 40% glycerol.
Sequence Length
567
Applicable Applications for anti-OCT-2 antibody
ELISA, Western Blot
Application Notes
Suitable for use in ELISA, Western Blot. Other applications not tested.
Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Immunogen
Synthetic peptide consisting of 21aa within the cytoplasmic, c-terminal domain of the rat Organic Cation Transporter 2 (KLH coupled).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-OCT-2 antibody
Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic cations from the blood by an active process called "renal secretion". Functional studies have identified two distinct categories of organic cation transporters (OCTs): a system driven by transmembrane potential difference that governs the influx of cations, whereas the H+-gradient-dependent transport system may mediate the efflux of organic cations. Several multispecific, potential-sensitive transporters (OCT1-3) and H+-dependent transporters (OCTN1-3) have been cloned and characterized from various tissues. OCT superfamily of proteins shares high degree of sequence homology, display up to 12 transmembrane domains with cytoplasmic N and C-terminus. Rat OCT2 was initially cloned from kidney by homology screening. OCT2 (rat 593aa, mouse 553aa, human 555aa) shares ~70% homology with OCT1. In rat, it is expressed primarily in kidney, and traces were found in colon stomach, and brain. Rat OCT2 has been localized to the basolateral membrane of S2 and S3 segments of proximal tubules. In contrast, OCT2 was localized to the luminal membranes of distal tubule. OCT2 also mediated uptake of a variety of organic cations.
Product Categories/Family for anti-OCT-2 antibody
References
• 1. Okuda, M., et al., BBRC 224: 500-507 (1996).
• 2. Mooslehner, K.A., et al., Mamm. Genome. 10: 218-224 (1999).
• 3. Gorbuleve, V., et al., DNA Cell Biol. 16: 871 (1997).
• 4. Koespell, H. Ann Rev. Physiol. 60: 243-266 (1998, review).
• 2. Mooslehner, K.A., et al., Mamm. Genome. 10: 218-224 (1999).
• 3. Gorbuleve, V., et al., DNA Cell Biol. 16: 871 (1997).
• 4. Koespell, H. Ann Rev. Physiol. 60: 243-266 (1998, review).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
63,167 Da
NCBI Official Full Name
organic cation transporter 2
NCBI Official Synonym Full Names
Organic cation transporter 2
NCBI Official Symbol
Orct2
NCBI Official Synonym Symbols
cald; CG13610; DmelCG13610; EP(3)1072; EP1072; orct2
NCBI Protein Information
CG13610 gene product from transcript CG13610-RA; organic cation transporter 2; CG13610-PA; Orct2-PA; EP1072; calderon
UniProt Protein Name
Organic cation transporter-like protein
UniProt Gene Name
Orct2
UniProt Entry Name
OCTL_DROME
Similar Products
Product Notes
The OCT-2 orct2 (Catalog #AAA618813) is an Antibody produced from Host: Rabbit Source: Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti - Oct-2 (Organic Cation Transporter 2) reacts with Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's OCT-2 can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot. Suitable for use in ELISA, Western Blot. Other applications not tested. Dilution: Western Blot: 1:1000-1:5000 (ECL). ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml. Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the OCT-2 orct2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OCT-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
