Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using OCA2 antibody.)
Rabbit anti-Human OCA2 Polyclonal Antibody | anti-OCA2 antibody
OCA2 Antibody
Immunohistochemistry: 1:50 - 1:200
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using OCA2 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using OCA2 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
OCA2: a transporer of tyrosine, a precursor for melanin synthesis, within melanocytes. Regulates the pH of melanosomes and melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the SLC13A transporter family.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q
Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; cytoplasm; melanosome membrane; integral to membrane; endosome membrane
Molecular Function: protein binding; transporter activity; L-tyrosine transmembrane transporter activity
Biological Process: melanin biosynthetic process; cell proliferation; tyrosine transport; melanocyte differentiation; eye pigment biosynthetic process; transmembrane transport; spermatid development
Disease: Albinism, Oculocutaneous, Type Ii; Skin/hair/eye Pigmentation, Variation In, 1
Research Articles on OCA2
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Product Notes
The OCA2 oca2 (Catalog #AAA9407619) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OCA2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's OCA2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500 - 1:2000 Immunohistochemistry: 1:50 - 1:200. Researchers should empirically determine the suitability of the OCA2 oca2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OCA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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