Rabbit anti-Human, Rat OCA2 Polyclonal Antibody | anti-OCA2 antibody

OCA2 Antibody

Cat. Num. AAA7107171

• Gene Names: OCA2; P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12
• Reactivity: Human, Rat
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G purified
• Synonyms: OCA2; Polyclonal Antibody; OCA2 Antibody; P protein; Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog; D15S12; P; anti-OCA2 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 838

• Applicable Applications for anti-OCA2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:5000
• Immunogen: Recombinant Human P protein (2-136AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: K562 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, U87 whole cell lysate, HL-60 whole cell lysate, Rat brain tissueAll lanes: OCA2 antibody at 8.93ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 93, 91, 75 KDaObserved band size: 93 KDa)

Related Product Information for anti-OCA2 antibody

Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.

Product Categories/Family for anti-OCA2 antibody

Tags & Cell Markers; Metabolism; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 157266326
• NCBI GeneID: 4948
• NCBI Accession #: NP_000266.2
• NCBI GenBank Nucleotide #: NM_000275.2
• UniProt Accession #: Q04671; Q15211; Q15212; Q96EN1; Q9UMI5
• Molecular Weight: 74,312 Da
• NCBI Official Full Name: P protein isoform 1
• NCBI Official Synonym Full Names: OCA2 melanosomal transmembrane protein
• NCBI Official Symbol: OCA2
• NCBI Official Synonym Symbols: P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12
• NCBI Protein Information: P protein
• UniProt Protein Name: P protein
• Protein Family: P protein
• UniProt Gene Name: OCA2
• UniProt Synonym Gene Names: D15S12; P

NCBI Description

This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.