Rabbit anti-Mouse OAS2 Polyclonal Antibody | anti-OAS2 antibody

OAS2 Rabbit pAb

Cat. Num. AAA4757833

• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: OAS2; Polyclonal Antibody; OAS2 Rabbit pAb; 2'-5'-oligoadenylate synthetase 2; 69/71kDa; anti-OAS2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-OAS2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:200-1:1000
• Immunogen: Fusion protein of human OAS2
• Conjugation: Unconjugated
• Modification: Unmodified
• Cell Position: Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Mouse heart tissue, Primary antibody: 821064(OAS2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds)

Product Categories/Family for anti-OAS2 antibody

Primary antibody

NCBI and Uniprot Product Information

• UniProt Accession #: P29728
• Molecular Weight: 82kDa
• UniProt Protein Name: 2'-5'-oligoadenylate synthase 2
• Protein Family: 2'-5'-oligoadenylate synthase
• UniProt Gene Name: OAS2
• UniProt Synonym Gene Names: (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69OAS / p71OAS
• UniProt Entry Name: OAS2_HUMAN

Uniprot Description

OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: mitochondrion; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; RNA catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; protein myristoylation; protein amino acid glycosylation; purine nucleotide biosynthetic process; defense response to virus