Western Blot (WB)
(Western blot analysis NUP214 using LOVO whole cell lysates)
Rabbit anti-Human, Mouse NUP214 Polyclonal Antibody | anti-NUP214 antibody
NUP214 Antibody
Western Blot (WB)
(Western blot analysis NUP214 using LOVO whole cell lysates)
Western Blot (WB)
(Western blot analysis NUP214 using LOVO whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Description
NUP214: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear export; Nucleoporin; Oncoprotein
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: cytosol; focal adhesion; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: nuclear export signal receptor activity; nuclear localization sequence binding; protein binding; structural constituent of nuclear pore
Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein export from nucleus; protein import into nucleus; protein sumoylation; regulation of mRNA stability; RNA export from nucleus; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription
Disease: Leukemia, Acute Lymphoblastic
Research Articles on NUP214
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Product Notes
The NUP214 nup214 (Catalog #AAA9419496) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NUP214 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NUP214 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000-3000. Researchers should empirically determine the suitability of the NUP214 nup214 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NUP214, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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