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Western Blot (WB) (Western blotAll lanes: NUMB antibody at 0.93ug/mlLane 1: Mouse brain tissueLane 2: A431 whole cell lysateLane 3: HepG-2 whole cell lysateLane 4: Mouse lung tissueLane 5: Hela whole cell lysateLane 6: Mouse heart tissueLane 7: Mouse kidney tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 71,66,70,65,56,54,51,49,38 kDaObserved band size: 71 kDa)

Rabbit anti-Human, Mouse NUMB Polyclonal Antibody | anti-NUMB antibody

NUMB Antibody

Gene Names
NUMB; S171; C14orf41; c14_5527
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
Antigen Affinity Purified
Synonyms
NUMB; Polyclonal Antibody; NUMB Antibody; Protein numb homolog; h-Numb; Protein S171; anti-NUMB antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Sequence Length
651
Applicable Applications for anti-NUMB antibody
ELISA (EIA), Western Blot (WB)
Species
Human
Immunogen
Recombinant human Protein numb homolog protein (C-120AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-25668
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: NUMB antibody at 0.93ug/mlLane 1: Mouse brain tissueLane 2: A431 whole cell lysateLane 3: HepG-2 whole cell lysateLane 4: Mouse lung tissueLane 5: Hela whole cell lysateLane 6: Mouse heart tissueLane 7: Mouse kidney tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 71,66,70,65,56,54,51,49,38 kDaObserved band size: 71 kDa)

Western Blot (WB) (Western blotAll lanes: NUMB antibody at 0.93ug/mlLane 1: Mouse brain tissueLane 2: A431 whole cell lysateLane 3: HepG-2 whole cell lysateLane 4: Mouse lung tissueLane 5: Hela whole cell lysateLane 6: Mouse heart tissueLane 7: Mouse kidney tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 71,66,70,65,56,54,51,49,38 kDaObserved band size: 71 kDa)
Related Product Information for anti-NUMB antibody
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37,396 Da
NCBI Official Full Name
protein numb homolog isoform 1
NCBI Official Synonym Full Names
NUMB, endocytic adaptor protein
NCBI Official Symbol
NUMB
NCBI Official Synonym Symbols
S171; C14orf41; c14_5527
NCBI Protein Information
protein numb homolog
UniProt Protein Name
Protein numb homolog
Protein Family
UniProt Gene Name
NUMB
UniProt Synonym Gene Names
h-Numb
UniProt Entry Name
NUMB_HUMAN

NCBI Description

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

NUMB: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: clathrin-coated vesicle; focal adhesion; plasma membrane

Molecular Function: protein binding

Biological Process: lateral ventricle development; neuroblast division in the subventricular zone; positive regulation of cell migration; positive regulation of neurogenesis

Research Articles on NUMB

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Product Notes

The NUMB numb (Catalog #AAA7046346) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NUMB Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NUMB can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the NUMB numb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NUMB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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