Rabbit NT5C Polyclonal Antibody | anti-NT5C antibody

NT5C Rabbit Polyclonal

Cat. Num. AAA7602106

• Gene Names: NT5C; DNT; cdN; DNT1; P5N2; PN-I; HEL74; PN-II; UMPH2; dNT-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: NT5C; Polyclonal Antibody; NT5C Rabbit Polyclonal; anti-NT5C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 117

• Applicable Applications for anti-NT5C antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: 5', 3'-nucleotidase, cytosolic
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using MBS7602106 (NT5C Antibody) at dilution of 1:50)

NCBI and Uniprot Product Information

• NCBI GI #: 14198247
• NCBI GeneID: 30833
• Molecular Weight: 13,299 Da
• NCBI Official Full Name: NT5C protein
• NCBI Official Synonym Full Names: 5', 3'-nucleotidase, cytosolic
• NCBI Official Symbol: NT5C
• NCBI Official Synonym Symbols: DNT; cdN; DNT1; P5N2; PN-I; HEL74; PN-II; UMPH2; dNT-1
• NCBI Protein Information: 5'(3')-deoxyribonucleotidase, cytosolic type
• UniProt Protein Name: 5'(3')-deoxyribonucleotidase, cytosolic type
• UniProt Gene Name: NT5C
• UniProt Synonym Gene Names: DNT1; UMPH2; dNT-1
• UniProt Entry Name: NT5C_HUMAN

NCBI Description

This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

NT5C: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Belongs to the 5'(3')-deoxyribonucleotidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; EC 3.1.3.-; Hydrolase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus

Molecular Function: 5'-nucleotidase activity; metal ion binding; nucleotidase activity; pyrimidine nucleotide binding

Biological Process: dephosphorylation; purine nucleotide catabolic process; pyrimidine deoxyribonucleotide catabolic process; pyrimidine nucleoside catabolic process