Sheep anti-Human NPTXR Polyclonal Antibody | anti-NPTXR antibody

NPTXR (Neuronal Pentraxin Receptor, NPR)

Cat. Num. AAA615188

• Gene Names: NPTXR; NPR
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: NPTXR; Polyclonal Antibody; NPTXR (Neuronal Pentraxin Receptor; NPR); Anti -NPTXR (Neuronal Pentraxin Receptor; anti-NPTXR antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NPTXR, extracellular domain. Displays less than 5% crossreacitvity with rhNPTX1 and rhNPTX2. Species Sequence Homology: Mouse - 87%.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 500ul sterile 40-50% glycerol, PBS.

• Applicable Applications for anti-NPTXR antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Direct ELISA: 0.5-1ug/ml; Detection limit for rhNPTXR is ~0.3ng/well.; Western Blot: 0.1-0.2ug/ml; Detection limit for rhNPTXR is ~20ng/lane and 1ng/lane under non-reducing and reducing conditions, respectively.; Immunohistochemistry: 3-10ug/ml
• Immunogen: Purified, NS0-derived, recombinant human NPTXR, aa24-499.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, PBS and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NPTXR antibody

NPTXR (Neuronal Pentraxin Receptor; also NPR) is a 65kD, type II transmembrane glycoprotein that binds Neuronal Pentraxins 1 and 2. It is expressed on cerebellar Purkinje and granule cells, and hippocampal neurons of the CA1, CA3 and dentate gyrus regions. Human NPTXR is 499 amino acids (aa) in length. It contains a two aa cytoplasmic tail, a 21aa transmembrane segment, and a 476aa extracellular region with one Pentraxin domain (aa295-499). One alternate start site exists at Met12, and a 55kD soluble form (possibly beginning at Gln56) may be generated by proteolytic cleavage.

Product Categories/Family for anti-NPTXR antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 17402888
• NCBI GeneID: 23467
• NCBI Accession #: NP_055108.2
• NCBI GenBank Nucleotide #: NM_014293.3
• UniProt Accession #: O95502
• Molecular Weight: 52,846 Da
• NCBI Official Full Name: neuronal pentraxin receptor
• NCBI Official Synonym Full Names: neuronal pentraxin receptor
• NCBI Official Symbol: NPTXR
• NCBI Official Synonym Symbols: NPR
• NCBI Protein Information: neuronal pentraxin receptor; OTTHUMP00000197414
• UniProt Protein Name: Neuronal pentraxin receptor
• Protein Family: Neuronal pentraxin receptor
• UniProt Gene Name: NPTXR
• UniProt Entry Name: NPTXR_HUMAN

NCBI Description

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq]

Uniprot Description

NPTXR: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2)

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: integral to membrane

Molecular Function: metal ion binding