Rabbit NPR1 Polyclonal Antibody | anti-NPR1 antibody

NPR1 Rabbit pAb

Cat. Num. AAA4754650

• Gene Names: NPR1; ANPa; NPRA; ANPRA; GUC2A; GUCY2A
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: NPR1; Polyclonal Antibody; NPR1 Rabbit pAb; Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); ANPa; NPRA; ANPRA; GUC2A; GUCY3A; anti-NPR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-NPR1 antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:1000-1:5000; IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human NPR1
• Conjugation: Unconjugated
• Molecular Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 160091(NPR1 Antibody) at dilution 1/30.(Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human brain tissue using 160091(NPR1 Antibody) at dilution 1/30. (Original magnification: ×200))

Related Product Information for anti-NPR1 antibody

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).

Product Categories/Family for anti-NPR1 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 167830411
• NCBI GeneID: 4881
• NCBI Accession #: NP_000897.3
• NCBI GenBank Nucleotide #: NM_000906.3
• UniProt Accession #: P16066; Q5SR08; Q6P4Q3; B0ZBF0
• Molecular Weight: 118,919 Da
• NCBI Official Full Name: atrial natriuretic peptide receptor 1
• NCBI Official Synonym Full Names: natriuretic peptide receptor 1
• NCBI Official Symbol: NPR1
• NCBI Official Synonym Symbols: ANPa; NPRA; ANPRA; GUC2A; GUCY2A
• NCBI Protein Information: atrial natriuretic peptide receptor 1
• UniProt Protein Name: Atrial natriuretic peptide receptor 1
• Protein Family: Nitrogen permease reactivator protein
• UniProt Gene Name: NPR1
• UniProt Synonym Gene Names: ANPRA; ANP-A; ANPR-A; NPR-A; GC-A

NCBI Description

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Uniprot Description

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.