Rabbit NPFFR1 / GPR147 Polyclonal Antibody | anti-NPFFR1 antibody

Rabbit Polyclonal to Human NPFFR1 / GPR147

Cat. Num. AAA247340

• Gene Names: NPFFR1; NPFF1; GPR147; NPFF1R1; OT7T022
• Reactivity: Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: NPFFR1 / GPR147; Polyclonal Antibody; Rabbit Polyclonal to Human NPFFR1 / GPR147; Anti-NPFFR1 / GPR147 Antibody (C-Terminus) IHC-plus; NPFFR1; G-protein coupled receptor 147; GPR147; Neuropeptide FF 1; Neuropeptide FF receptor 1; NPFF-R1; OT7T022; NPFF1 receptor; G protein-coupled receptor 147; Neuropeptide FF1 receptor; NPFF1; NPFF1R1; Human NPFFR1; anti-NPFFR1 antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human NPFF1 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 430

• Applicable Applications for anti-NPFFR1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 - 40 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from C-terminus of human NPFF1 Receptor. Percent identity with other species by BLAST analysis: Human (100%); Gibbon (95%); Gorilla (85%); Monkey, Elephant (80%).
• Immunogen Type: Synthetic peptide
• Immunogen: NPFFR1 / GPR147 antibody was raised against synthetic 20 amino acid peptide from C-terminus of human NPFF1 Receptor. Percent identity with other species by BLAST analysis: Human (100%); Gibbon (95%); Gorilla (85%); Monkey, Elephant (80%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-NPFFR1 / GPR147 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NPFF1 Receptor antibody IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NPFFR1 / GPR147 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NPFFR1 / GPR147 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-NPFFR1 antibody

The Neuropeptide FF 1 Receptor (NPFF1) is a member of the Neuropeptide Receptor GPCR family. The ligand, neuropeptide FF, is believed to play a role in pain modulation and opiate tolerance.

Product Categories/Family for anti-NPFFR1 antibody

Family: GPCR; Subfamily: Neuropeptide

NCBI and Uniprot Product Information

• NCBI GI #: 11545887
• NCBI GeneID: 64106
• NCBI Accession #: NP_071429.1
• NCBI GenBank Nucleotide #: NM_022146.4
• UniProt Accession #: Q9GZQ6; Q8NGR0; Q96RN3; A2RRF0
• Molecular Weight: 47,819 Da
• NCBI Official Full Name: neuropeptide FF receptor 1
• NCBI Official Synonym Full Names: neuropeptide FF receptor 1
• NCBI Official Symbol: NPFFR1
• NCBI Official Synonym Symbols: NPFF1; GPR147; NPFF1R1; OT7T022
• NCBI Protein Information: neuropeptide FF receptor 1; neuropeptide FF 1; G protein-coupled receptor 147; G-protein coupled receptor 147; RFamide-related peptide receptor OT7T022
• UniProt Protein Name: Neuropeptide FF receptor 1
• Protein Family: Neuropeptide FF receptor
• UniProt Gene Name: NPFFR1
• UniProt Synonym Gene Names: GPR147; NPFF1
• UniProt Entry Name: NPFF1_HUMAN

Uniprot Description

NPFFR1: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q21-q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide receptor activity; peptide binding

Biological Process: synaptic transmission; neuropeptide signaling pathway; cellular response to hormone stimulus