Rabbit anti-Human NP-4 Polyclonal Antibody | anti-Np4 antibody

NP-4 (alpha Defensin-4)

Cat. Num. AAA611315

• Gene Names: Np4; NP-4
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: NP-4; Polyclonal Antibody; NP-4 (alpha Defensin-4); Anti -NP-4 (alpha Defensin-4); anti-Np4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NP-4 (alpha Defensin-4). No significant homology exists with other alpha-defensins.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-Np4 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000-1:5000; ELISA: 1:10,000-50,000. N5378 Control peptide can be used to coat ELISA plates at 1ug/ml.
• Immunogen: Synthetic peptide corresponding to 17aa near the C-terminus of mature human alpha Defensin-4 conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Np4 antibody

Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic/polar peptides (30-35 aa; 3-4kD), are distinguished by a conserved tri-disulfides and a largely b-sheet structure. Defensins, expressed at the cell surface, have been hypothesized to function as a biochemical barrier against microbial infection by inhibiting colonization of the epithelium by wide range of pathogenic microorganisms. In leukocytes, these peptides are stored in cytoplasmic granules and are released into phagolysosomes where they contribute to the killing of engulfed microorganisms. The genes encoding human alpha and beta-defensins are clustered in a contiguous segment of chromosome 8p23. Defensins are classified into two families designated alpha and beta based on distinctive, although similar, tri-disulfide linkages in the peptides. b-defensins are slightly larger and differ in the position and arrangement of 3 disulfides. In humans, six a-defensin (cryptidins), HD 1-6 (HD1-4 are also known as HNP1-4 for Human Neutrophil Peptides), and two b-defensins, HBD-1 and HBD-2, have been identified.

Product Categories/Family for anti-Np4 antibody

Antibodies; Abs to Defensin

NCBI and Uniprot Product Information

• NCBI GI #: 27545366
• NCBI GeneID: 286958
• NCBI Accession #: NP_775421.1
• NCBI GenBank Nucleotide #: NM_173299.1
• UniProt Accession #: Q62714
• Molecular Weight: 10,110 Da
• NCBI Official Full Name: neutrophil antibiotic peptide NP-4
• NCBI Official Synonym Full Names: defensin NP-4 precursor
• NCBI Official Symbol: Np4
• NCBI Official Synonym Symbols: NP-4
• NCBI Protein Information: neutrophil antibiotic peptide NP-4; ratNP-4; defensin 3b; neutrophil defensin 4
• UniProt Protein Name: Neutrophil antibiotic peptide NP-4
• UniProt Gene Name: Np4
• UniProt Entry Name: DEF4_RAT

NCBI Description

antimicrobial peptide found in cytoplasmic granules of neutrophils [RGD]

Uniprot Description

Function: Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.

Subcellular location: Secreted.

Tissue specificity: Highest expression in bone marrow and to a much lesser extent in small intestine.

Sequence similarities: Belongs to the alpha-defensin family.