Testing Data #1
(Staining of formalin fixed, paraffin embedded human colon with Rabbit anti human NOXO1 (MBS223756))
Rabbit NOXO1 Polyclonal Antibody | anti-NOXO1 antibody
RABBIT ANTI HUMAN NOXO1
NOXO1 is found in a range of tissues types, being highly expressed in colon epithelial tissue, and occurs in multiple isoforms generated by alternative splicing.
Purified IgG - liquid
ELISA: Minimum Dilution: 1:20000; Maximum Dilution: 1:100000
Immunohistology - Paraffin: Minimum Dilution: 5; Maximum Dilution: 10ug/ml
Western Blotting: Minimum Dilution: 1:2000; Maximum Dilution: 1:8000
Histology Positive Control Tissue
Shelf Life: 18 months from date of despatch.
Testing Data #1
(Staining of formalin fixed, paraffin embedded human colon with Rabbit anti human NOXO1 (MBS223756))
Testing Data #1
(Staining of formalin fixed, paraffin embedded human colon with Rabbit anti human NOXO1 (MBS223756))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Uniprot Description
NOXO1: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: NADPH oxidase complex
Molecular Function: identical protein binding; protein binding; enzyme binding; superoxide-generating NADPH oxidase activator activity; phospholipid binding; phosphoinositide binding
Biological Process: positive regulation of catalytic activity; extracellular matrix disassembly; superoxide metabolic process; regulation of hydrogen peroxide metabolic process
Research Articles on NOXO1
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Product Notes
The NOXO1 noxo1 (Catalog #AAA223756) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI HUMAN NOXO1 reacts with Chimpanzee (Expected from Sequence) and may cross-react with other species as described in the data sheet. AAA Biotech's NOXO1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin, Western Blot (WB). Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. ELISA: Minimum Dilution: 1:20000; Maximum Dilution: 1:100000 Immunohistology - Paraffin: Minimum Dilution: 5; Maximum Dilution: 10ug/ml Western Blotting: Minimum Dilution: 1:2000; Maximum Dilution: 1:8000. Researchers should empirically determine the suitability of the NOXO1 noxo1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOXO1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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