Rabbit NOVA2 Polyclonal Antibody | anti-NOVA2 antibody

Anti-NOVA2 Antibody

Cat. Num. AAA1753172

• Gene Names: NOVA2; ANOVA; NOVA3; NEDASB; NOVA-2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay, ELISA
• Purity: Immunogen affinity purified.
• Synonyms: NOVA2; Polyclonal Antibody; Anti-NOVA2 Antibody; RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; ANOVA; NOVA3; anti-NOVA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 492

• Applicable Applications for anti-NOVA2 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS), Direct ELISA (EIA)
• Application Notes: WB: 0.25-0.5ug/ml (Human, Mouse, Rat); IHC-P (Embedded Section): 0.5-1ug/ml (Human, Mouse, Rat); FC/FACS: 1-3ug/1x106 cells (Human, Mouse); Direct ELISA: 0.1-0.5ug/ml (Human); Tested Species: In-house tested species with positive results.
• Immunogen: E Coli-derived human NOVA2 recombinant protein (Position: M1-Q205).
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Related Product Information for anti-NOVA2 antibody

Description: Rabbit IgG polyclonal antibody for NOVA2 detection. Tested with WB, IHC-P, FCM, Direct ELISA in Human; Mouse; Rat.

Background: NOVA alternative splicing regulator 2 is a protein that in humans is encoded by the NOVA2 gene. It is mapped to 19q13.32. NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It binds single strand RNA.

References

1. Heinzen, E. L., Yoon, W., Tate, S. K., Sen, A., Wood, N. W., Sisodiya, S. M., Goldstein, D. B. Nova2 interacts with a Cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am. J. Hum. Genet. 80: 876-883, 2007.
2. Lewis, H. A., Musunuru, K., Jensen, K. B., Edo, C., Chen, H., Darnell, R. B., Burley, S. K. Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. Cell 100: 323-332, 2000.
3. Saito, Y., Yuan, Y., Zucker-Scharff, I., Fak, J. J., Jereb, S., Tajima, Y., Licatalosi, D. D., Darnell, R. B. Differential NOVA2-mediated splicing in excitatory and inhibitory neurons regulates cortical development and cerebellar function. Neuron 101: 707-720, 2019.

NCBI and Uniprot Product Information

• NCBI GI #: 5902724
• NCBI GeneID: 4858
• NCBI Accession #: NP_002507.1
• NCBI GenBank Nucleotide #: NP_002507.1
• UniProt Accession #: Q9UNW9
• NCBI Official Full Name: RNA-binding protein Nova-2
• NCBI Official Synonym Full Names: NOVA alternative splicing regulator 2
• NCBI Official Symbol: NOVA2
• NCBI Official Synonym Symbols: ANOVA; NOVA3; NEDASB; NOVA-2
• NCBI Protein Information: RNA-binding protein Nova-2
• UniProt Protein Name: RNA-binding protein Nova-2
• Protein Family: RNA-binding protein
• UniProt Gene Name: NOVA2
• UniProt Synonym Gene Names: ANOVA; NOVA3
• UniProt Entry Name: NOVA2_HUMAN

Uniprot Description

NOVA2: May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleus

Molecular Function: RNA binding

Biological Process: regulation of RNA metabolic process