Western Blot (WB)
(WB: Lamdba phosphatase treated (Lane 1) and untreated (Lane 2) affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK was probed with MBS629394 (0.5ug/ml).)
Rabbit anti-Human, Rat NOS I Polyclonal Antibody | anti-NOS-1 antibody
NOS I, Phosphorylated (Ser1417) (Neuronal Nitric Oxide Synthase, bNOS, nNOS, NOS-1) (MaxLight 750)
WB: 1:500 detects affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK in vitro. Lambda phosphatase treated and untreated affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK was resolved by electrophoresis, transferred to PVDF and probed with. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Western Blot (WB)
(WB: Lamdba phosphatase treated (Lane 1) and untreated (Lane 2) affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK was probed with MBS629394 (0.5ug/ml).)
Western Blot (WB)
(WB: Lamdba phosphatase treated (Lane 1) and untreated (Lane 2) affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK was probed with MBS629394 (0.5ug/ml).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Description
nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described.
Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q24.22
Cellular Component: photoreceptor inner segment; protein complex; cytoskeleton; sarcoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; cytoplasm; dendritic spine; synapse; cytosol; sarcolemma; lipid raft
Molecular Function: calmodulin binding; protein binding; sodium channel regulator activity; FAD binding; NADPH-hemoprotein reductase activity; FMN binding; nitric-oxide synthase activity; iron ion binding; heme binding; oxidoreductase activity; NADP binding; cadmium ion binding
Biological Process: interaction with host; negative regulation of serotonin uptake; negative regulation of calcium ion transport; striated muscle contraction; positive regulation of transcription, DNA-dependent; negative regulation of potassium ion transport; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; positive regulation of vasodilation; response to heat; negative regulation of hydrolase activity; exogenous drug catabolic process; response to hypoxia; peptidyl-cysteine S-nitrosylation; arginine catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; negative regulation of blood pressure; nitric oxide biosynthetic process; blood coagulation; nitric oxide mediated signal transduction; multicellular organismal response to stress; myoblast fusion; neurotransmitter biosynthetic process
Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
Research Articles on NOS-1
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Product Notes
The NOS-1 nos1 (Catalog #AAA6490295) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NOS I, Phosphorylated (Ser1417) (Neuronal Nitric Oxide Synthase, bNOS, nNOS, NOS-1) (MaxLight 750) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NOS I can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. WB: 1:500 detects affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK in vitro. Lambda phosphatase treated and untreated affinity purified bacterial expressed rat nNOS/NOS I that had been phosphorylated by purified AMPK was resolved by electrophoresis, transferred to PVDF and probed with. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Researchers should empirically determine the suitability of the NOS-1 nos1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOS I, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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