Western Blot (WB)
(Western blot analysis of NMDAR2C expression in U87MG (A), Panc1 (B) whole cell lysates.)
Rabbit anti-Human NMDAR2C Polyclonal Antibody | anti-NMDAR2C antibody
Anti-NMDAR2C Antibody
IHC: 1:50-1:200
Western Blot (WB)
(Western blot analysis of NMDAR2C expression in U87MG (A), Panc1 (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of NMDAR2C expression in U87MG (A), Panc1 (B) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of NMDAR2C staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of NMDAR2C staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Description
NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: postsynaptic membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein N-terminus binding; cation channel activity; PDZ domain binding
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; protein localization; transport; directional locomotion; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; response to wounding; regulation of excitatory postsynaptic membrane potential; neuromuscular process controlling balance; negative regulation of protein catabolic process
Research Articles on NMDAR2C
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Product Notes
The NMDAR2C grin2c (Catalog #AAA8305816) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-NMDAR2C Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NMDAR2C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:1000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the NMDAR2C grin2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NMDAR2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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