Western Blot (WB)
(Anti- NMDAR2B Picoband antibody, MBS177759, Western blottingAll lanes: Anti NMDAR2B (MBS177759) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 166KDObserved bind size: 220KD )
NMDAR2B Polyclonal Antibody | anti-NMDAR2B antibody
Anti-NMDAR2B Antibody
Predicted to work with: Human
Predicted to work with: Human
Western Blot (WB)
(Anti- NMDAR2B Picoband antibody, MBS177759, Western blottingAll lanes: Anti NMDAR2B (MBS177759) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 166KDObserved bind size: 220KD )
Western Blot (WB)
(Anti- NMDAR2B Picoband antibody, MBS177759, Western blottingAll lanes: Anti NMDAR2B (MBS177759) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 166KDObserved bind size: 220KD )
Background: The N-methyl-D-aspartate receptor 2B (NMDAR2B), also names as GRIN2B. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively. Nmdar2B gene is located on mouse chromosome 6 between Rho and Ly49 centromerically and Glb telomerically. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12 overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz.
NCBI and Uniprot Product Information
NCBI Description
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Uniprot Description
NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.
Protein type: Membrane protein, integral; Channel, ligand-gated; Channel, calcium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: cell junction; cell surface; integral to plasma membrane; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane
Molecular Function: extracellular-glutamate-gated ion channel activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; positive regulation of GTPase activity; response to ethanol; synaptic transmission; transport
Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6
Research Articles on NMDAR2B
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Product Notes
The NMDAR2B grin2b (Catalog #AAA177759) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-NMDAR2B Antibody reacts with Mouse, Rat Predicted to work with: Human and may cross-react with other species as described in the data sheet. AAA Biotech's NMDAR2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the NMDAR2B grin2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NMDAR2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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