Rabbit NMDAR1 Polyclonal Antibody | anti-NMDAR1 antibody

NMDAR1 (Phospho-Ser896) Antibody

Cat. Num. AAA9401431

• Gene Names: GRIN1; NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Synonyms: NMDAR1; Polyclonal Antibody; NMDAR1 (Phospho-Ser896) Antibody; GLURZ1; GRIN1; NMD-R1; NMDZ1; NMZ1; anti-NMDAR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of NMDAR1 only when phosphorylated at serine896.
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 885

• Applicable Applications for anti-NMDAR1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:1000
• Immunogen Type: Peptide-KLH
• Immunogen Description: Peptide sequence around phosphorylation site of serine 896 (R-R-S(p)-S-K) derived from Human NMDAR1.
• Modification: Phospho-Ser896
• Target Name: NMDAR1
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Western Blot (WB)

(Western blot analysis of extracts from Mouse Brain tissue using NMDAR1(Phospho-Ser896) Antibody.)

Related Product Information for anti-NMDAR1 antibody

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Product Categories/Family for anti-NMDAR1 antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 11496971
• NCBI GeneID: 2902
• NCBI Accession #: NP_000823.4
• NCBI GenBank Nucleotide #: NM_000832.6
• UniProt Accession #: Q05586; P35437; Q12867; Q12868; Q5VSF3; Q5VSF4; Q5VSF5; Q5VSF6; Q5VSF7; A6NLK7; A6NLR1; C9K0X1
• Molecular Weight: 101,851 Da
• NCBI Official Full Name: glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, N-methyl D-aspartate 1
• NCBI Official Symbol: GRIN1
• NCBI Official Synonym Symbols: NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
• NCBI Protein Information: glutamate receptor ionotropic, NMDA 1
• UniProt Protein Name: Glutamate receptor ionotropic, NMDA 1
• Protein Family: Glutamate [NMDA] receptor
• UniProt Gene Name: GRIN1
• UniProt Synonym Gene Names: NMDAR1; GluN1; NMD-R1
• UniProt Entry Name: NMDZ1_HUMAN

NCBI Description

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: neuron projection; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; postsynaptic density; dendritic spine; terminal button; excitatory synapse; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; plasma membrane; synapse; cell junction

Molecular Function: voltage-gated cation channel activity; calmodulin binding; neurotransmitter binding; protein binding; glutamate receptor binding; enzyme binding; glutamate binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; calcium channel activity; calcium ion binding

Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; male mating behavior; prepulse inhibition; positive regulation of apoptosis; adult locomotory behavior; regulation of dendrite morphogenesis; rhythmic process; response to morphine; sensory perception of pain; regulation of axonogenesis; calcium ion homeostasis; synaptic transmission; regulation of respiratory gaseous exchange; conditioned taste aversion; ephrin receptor signaling pathway; visual learning; negative regulation of neuron apoptosis; cation transport; protein tetramerization; synaptic transmission, glutamatergic; response to amphetamine; social behavior; respiratory gaseous exchange; pons maturation; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; suckling behavior; regulation of synaptogenesis; propylene metabolic process; long-term memory; olfactory learning; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential

Disease: Mental Retardation, Autosomal Dominant 8