Rabbit NLRP6 Polyclonal Antibody | anti-NLRP6 antibody

NLRP6 Polyclonal Antibody

Cat. Num. AAA3010696

• Gene Names: NLRP6; AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NLRP6; Polyclonal Antibody; NLRP6 Polyclonal Antibody; anti-NLRP6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NLRP6 polyclonal antibody detects endogenous levels of NLRP6 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 892

• Applicable Applications for anti-NLRP6 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using NLRP6 antibody.)

Related Product Information for anti-NLRP6 antibody

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 452085171
• NCBI GeneID: 171389
• NCBI Accession #: NP_612202
• NCBI GenBank Nucleotide #: NP_612202.2
• UniProt Accession #: P59044
• Molecular Weight: 110kDa
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 6 isoform 1
• NCBI Official Synonym Full Names: NLR family pyrin domain containing 6
• NCBI Official Symbol: NLRP6
• NCBI Official Synonym Symbols: AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 6
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 6
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP6
• UniProt Synonym Gene Names: NALP6; PYPAF5
• UniProt Entry Name: NALP6_HUMAN

NCBI Description

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Description

NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nuclear membrane; cytoplasm; plasma membrane

Molecular Function: ATP binding; vasopressin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; wound healing; response to bacterium; negative regulation of MAPKKK cascade; regulation of inflammatory response; negative regulation of immune response; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; negative regulation of I-kappaB kinase/NF-kappaB cascade