Western Blot (WB)
(NKX6-1 Antibody (C-term) (MBS9211953) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).)
Rabbit NKX6-1 Polyclonal Antibody | anti-NKX6-1 antibody
NKX6-1 Antibody (C-term)
Western Blot (WB)
(NKX6-1 Antibody (C-term) (MBS9211953) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).)
Western Blot (WB)
(NKX6-1 Antibody (C-term) (MBS9211953) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).)
Western Blot (WB)
(NKX6-1 Antibody (C-term) (MBS9211953) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).)
Western Blot (WB)
(NKX6-1 Antibody (C-term) (MBS9211953) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).)
beta cells and is a potent bifunctional transcription regulator
that binds to AT-rich sequences within the promoter region of
target genes Iype et al. (2004) [PubMed 15056733].[supplied by
OMIM].
Zhu, S., et al. Dig. Dis. Sci. 54(5):996-1002(2009)
Schisler, J.C., et al. Mol. Cell. Biol. 28(10):3465-3476(2008)
Yokoi, N., et al. Diabetes 55(8):2379-2386(2006)
Hori, Y., et al. PLoS Med. 2 (4), E103 (2005) :
NCBI and Uniprot Product Information
NCBI Description
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
Uniprot Description
NKX6-1: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.
Protein type: Cell development/differentiation; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 4q21.33
Cellular Component: nucleoplasm
Molecular Function: chromatin binding
Biological Process: transcription from RNA polymerase II promoter; response to drug; response to nicotine; smoothened signaling pathway; positive regulation of insulin secretion; positive regulation of glial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of axon extension; endocrine pancreas development; negative regulation of glial cell differentiation; cell proliferation; detection of glucose; organ morphogenesis; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; pancreas development; oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; positive regulation of neuron differentiation
Research Articles on NKX6-1
Similar Products
Product Notes
The NKX6-1 nkx6-1 (Catalog #AAA9211953) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 6-1. The NKX6-1 Antibody (C-term) reacts with Human, mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's NKX6-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the NKX6-1 nkx6-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NKX6-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
