Rabbit anti-Human, Mouse NKIRAS1 Polyclonal Antibody | anti-NKIRAS1 antibody

NKIRAS1 Conjugated Antibody

Cat. Num. AAA9453637

• Gene Names: NKIRAS1; KBRAS1; kappaB-Ras1
• Reactivity: Human, Mouse
• Applications: Most Applications
• Synonyms: NKIRAS1; Polyclonal Antibody; NKIRAS1 Conjugated Antibody; Kappa B-Ras protein 1; Kappa B-ras 1; KappaB-Ras1; KBRAS1; anti-NKIRAS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: NKIRAS1 antibody detects endogenous levels of total NKIRAS1
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-NKIRAS1 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: A synthesized peptide derived from human NKIRAS1
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 9966809
• NCBI GeneID: 28512
• NCBI Accession #: NP_065078.1
• NCBI GenBank Nucleotide #: NM_020345.3
• UniProt Accession #: Q9NYS0; Q96K18
• Molecular Weight: 21,643 Da
• NCBI Official Full Name: NF-kappa-B inhibitor-interacting Ras-like protein 1
• NCBI Official Synonym Full Names: NFKB inhibitor interacting Ras-like 1
• NCBI Official Symbol: NKIRAS1
• NCBI Official Synonym Symbols: KBRAS1; kappaB-Ras1
• NCBI Protein Information: NF-kappa-B inhibitor-interacting Ras-like protein 1; I-kappa-B-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1; kappa B-Ras protein 1; kappa B-ras 1
• UniProt Protein Name: NF-kappa-B inhibitor-interacting Ras-like protein 1
• Protein Family: NF-kappa-B inhibitor-interacting Ras-like protein
• UniProt Gene Name: NKIRAS1
• UniProt Synonym Gene Names: KBRAS1; Kappa B-Ras protein 1; KappaB-Ras1
• UniProt Entry Name: KBRS1_HUMAN

Uniprot Description

NKIRAS1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: membrane; cytoplasm

Molecular Function: GTPase activity; GTP binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; metabolic process; small GTPase mediated signal transduction