Rabbit NKCC1 Polyclonal Antibody | anti-SLC12A2 antibody
Anti-NKCC1 antibody
Predicted to work with: Mouse
Predicted to work with: Mouse
Concentration: 0.1-0.5 ug/ml
Tested Species: Hu
Predicted Species: Ms, Rat
Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1 ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: By Heat
Immunohistochemistry (Frozen Section):
Concentration: 0.5-1 ug/ml
Tested Species: Rat
Predicted Species: Hu, Ms
Tested Species: In-House tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins, is required for the staining of formalin/paraffin sections.
Other applications have not been tested. Optimal dilutions should be determined by end user.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
NKCC1: a multi-pass membrane cation transporter protein. Aids transcellular movement of chloride across both secretory and absorptive epithelia. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Expressed in many tissues. Bumetanide is a potent NKCC1 antagonist. Two alternatively spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5q23.3
Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; vesicle
Molecular Function: protein binding; ammonium transmembrane transporter activity; sodium:potassium:chloride symporter activity
Biological Process: hyperosmotic response; transport; transepithelial chloride transport; multicellular organism growth; sodium ion transport; ion transport; detection of mechanical stimulus involved in sensory perception of sound; transmembrane transport; positive regulation of cell volume; ammonium transport; gamma-aminobutyric acid signaling pathway; potassium ion transport
Research Articles on SLC12A2
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Product Notes
The SLC12A2 slc12a2 (Catalog #AAA176766) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-NKCC1 antibody reacts with Reacts with: Human, Rat Predicted to work with: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NKCC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Frozen Section. Western Blot: Concentration: 0.1-0.5 ug/ml Tested Species: Hu Predicted Species: Ms, Rat Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1 ug/ml Tested Species: Hu, Rat Predicted Species: Ms Antigen Retrieval: By Heat Immunohistochemistry (Frozen Section): Concentration: 0.5-1 ug/ml Tested Species: Rat Predicted Species: Hu, Ms Tested Species: In-House tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins, is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end user. Researchers should empirically determine the suitability of the SLC12A2 slc12a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NKCC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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