Western Blot (WB)
(Lane 1:A549 cell Lysate; Lane 2:U87 cell Lysate; Lane 3:COLO320 cell Lysate; Lane 4:SCG cell Lysate; Lane 5:PANC cell Lysate)
Rabbit NK1R Polyclonal Antibody | anti-NK1R antibody
NK1R antibody
Applications
Western Blot
Purity
NK1R antibody was purified by affinity chromatography
Synonyms
NK1R; Polyclonal Antibody; NK1R antibody; Polyclonal NK1R; Anti-NK1R; SPR; Tachykinin receptor 1; NKR-1; Substance P receptor; NKR 1; Neurokinin 1 receptor; TACR1; anti-NK1R antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
NK1R antibody was purified by affinity chromatography
Form/Format
Supplied in lyophilized form
Sequence Length
426
Applicable Applications for anti-NK1R antibody
Western Blot (WB)
Application Notes
Optimal conditions to be determined by the end user
Biological Significance
NK1R is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation.
Immunogen
NK1R antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle region of human TACR1, identical to the related rat and Rabbit sequences, as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C, avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Lane 1:A549 cell Lysate; Lane 2:U87 cell Lysate; Lane 3:COLO320 cell Lysate; Lane 4:SCG cell Lysate; Lane 5:PANC cell Lysate)
Western Blot (WB)
(Lane 1:A549 cell Lysate; Lane 2:U87 cell Lysate; Lane 3:COLO320 cell Lysate; Lane 4:SCG cell Lysate; Lane 5:PANC cell Lysate)
Related Product Information for anti-NK1R antibody
Affinity purified Rabbit polyclonal NK1R antibody
Product Categories/Family for anti-NK1R antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
48,945 Da
NCBI Official Full Name
neurokinin 1 receptor
UniProt Protein Name
Neurokinin 1 receptor
UniProt Gene Name
NK1R
UniProt Entry Name
A0A075BD60_CTEID
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Product Notes
The NK1R nk1r (Catalog #AAA5300436) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's NK1R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Optimal conditions to be determined by the end user. Researchers should empirically determine the suitability of the NK1R nk1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NK1R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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