Rabbit anti-Human NIX Polyclonal Antibody | anti-NIX antibody

NIX, ID (BNIP3L, BNIP3A, BNIP3H, NIX, BCL2/adenovirus E1B 19kD protein-interacting protein 3-like, Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19kD protein-interacting protein 3A, NIP3-like protein X) (MaxLight 405)

Cat. Num. AAA6325394

• Gene Names: BNIP3L; NIX; BNIP3a
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NIX; Polyclonal Antibody; ID (BNIP3L; BNIP3A; BNIP3H; BCL2/adenovirus E1B 19kD protein-interacting protein 3-like; Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19kD protein-interacting protein 3A; NIP3-like protein X) (MaxLight 405); BNIP3L; NIP3-like protein X; anti-NIX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-NIX antibody: Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; IF: 1:10-50; IHC: 1:50-100; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: NIX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-89 amino acids from the Central region of human NIX.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-NIX antibody

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.

Product Categories/Family for anti-NIX antibody

Antibodies; Infectious Disease Adenovirus

References

Novak, I., et al. EMBO Rep. 11(1):45-51(2010). Bellot, G., et al. Mol. Cell. Biol. 29(10):2570-2581(2009). Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008). Papandreou, I., et al. Cell Death Differ. 15(10):1572-1581(2008). Liu, W., et al. Neoplasia 10(8):897-907(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 4757860
• NCBI GeneID: 665
• NCBI Accession #: NP_004322.1
• NCBI GenBank Nucleotide #: NM_004331.2
• UniProt Accession #: O60238; Q5JW63; Q8NF87; Q6IBV1; Q9H3K3
• Molecular Weight: 23,930 Da
• NCBI Official Full Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
• NCBI Official Synonym Full Names: BCL2/adenovirus E1B 19kDa interacting protein 3-like
• NCBI Official Symbol: BNIP3L
• NCBI Official Synonym Symbols: NIX; BNIP3a
• NCBI Protein Information: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; OTTHUMP00000125280; OTTHUMP00000225446; OTTHUMP00000225447; OTTHUMP00000225448; OTTHUMP00000225568; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd
• UniProt Protein Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
• UniProt Gene Name: BNIP3L
• UniProt Synonym Gene Names: BNIP3A; BNIP3H; NIX; NIP3L
• UniProt Entry Name: BNI3L_HUMAN

NCBI Description

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq]

Uniprot Description

BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family.

Protein type: Apoptosis; Membrane protein, integral; Mitochondrial; Endoplasmic reticulum; Nuclear envelope

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; nuclear envelope; intrinsic to membrane

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding

Biological Process: viral reproduction; positive regulation of apoptosis; defense response to virus; negative regulation of apoptosis