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Immunohistochemistry (IHC) (The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (NIPBL Antibody) at dilution 1/55.)

Rabbit anti-Human, Mouse NIPBL Polyclonal Antibody | anti-NIPBL antibody

NIPBL Antibody

Gene Names
NIPBL; CDLS; IDN3; Scc2; CDLS1; IDN3-B
Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
NIPBL; Polyclonal Antibody; NIPBL Antibody; CDLS; IDN3; Scc2; CDLS1; IDN3-B; anti-NIPBL antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Antigen affinity purification
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
0.9mg/mL (varies by lot)
Applicable Applications for anti-NIPBL antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
Fusion protein of human NIPBL
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C for 1 year.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (NIPBL Antibody) at dilution 1/55.)

Immunohistochemistry (IHC) (The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (NIPBL Antibody) at dilution 1/55.)
Related Product Information for anti-NIPBL antibody
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-NIPBL antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
122,367 Da
NCBI Official Full Name
Homo sapiens Nipped-B homolog (Drosophila), mRNA
NCBI Official Synonym Full Names
NIPBL, cohesin loading factor
NCBI Official Symbol
NIPBL
NCBI Official Synonym Symbols
CDLS; IDN3; Scc2; CDLS1; IDN3-B
NCBI Protein Information
nipped-B-like protein
UniProt Protein Name
Regulating synaptic membrane exocytosis protein 3
Protein Family
UniProt Gene Name
RIMS3
UniProt Synonym Gene Names
KIAA0237; Nim3; RIM 3
UniProt Entry Name
RIMS3_HUMAN

NCBI Description

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RIMS3: Regulates synaptic membrane exocytosis.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: presynaptic active zone; cell junction

Biological Process: regulation of membrane potential; neurotransmitter transport; calcium ion-dependent exocytosis

Research Articles on NIPBL

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Product Notes

The NIPBL rims3 (Catalog #AAA9434817) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NIPBL Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NIPBL can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the NIPBL rims3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NIPBL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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